Document Detail


Promoter polymorphism of interleukin-18 in angiographically proven coronary artery disease.
MedLine Citation:
PMID:  18599493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin 18 (IL-18) is a pro-atherogenic cytokine associated with the occurrence of various cardiac complications. The IL-18 gene has a functional -137 G/C polymorphism (rs187238) in the promoter region. Using the ligase detection reaction-polymerase chain reaction, we genotyped a cohort of patients in Chinese Han population in Xiangfan region. Case patients of coronary artery disease and control patients were identified by coronary angiography. The plasma IL-18 concentrations were measured by ELISA. A significant increase of G allele or GG-genotype was observed in 241 case patients compared to 145 control individuals (frequency of G allele = 0.90 vs 0.83, p=0.004; frequency of GG-genotype = 0.81 vs 0.68, p = 0.005). In case patients, G allele carriers in multi-vessel disease patients had a higher occurrence rate when compared to single-vessel disease patients, but no significant difference was detected (frequency of G allele = 0.92 vs 0.88, p=0.107; frequency of GG-genotype = 0.84 vs 0.75, p = 0.089). IL-18 protein concentration of the -137GG genotype was much higher than concentration of the CG and CC genotype (case patients: 229.1+/-131.5 vs 122.7+/-73.6 pg/ml, P < 0.001; control patients: 65.9+/-31.6 vs 42.4+/-19.5 pg/ml, P < 0.001). To conclude, IL-18 promoter -137G/C polymorphism influences IL-18 levels and the occurrence of coronary artery disease, suggesting that IL-18 is causally involved in the development of atherosclerosis.
Authors:
Wenwei Liu; Qizhu Tang; Hua Jiang; Xiangwu Ding; Yongsheng Liu; Rui Zhu; Yongqian Tang; Bin Li; Min Wei
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-07-03
Journal Detail:
Title:  Angiology     Volume:  60     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2009 Apr-May
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Xiangfan Central Hospital, Xiangfan, Hubei, China. liuwenwei@medmail.com.cn
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MeSH Terms
Descriptor/Qualifier:
Alleles
Coronary Angiography / methods*
Coronary Artery Disease / blood,  genetics*,  radiography
DNA / genetics*
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-18 / blood,  genetics*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Prognosis
Promoter Regions, Genetic*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Interleukin-18; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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