| The Promoter Variant -803 G>A in the RBP4 gene is not Associated with BMI, Metabolic Parameters or Blood Pressure in Caucasian Children. | |
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MedLine Citation:
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PMID: 22068556 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.We genotyped this polymorphism in a cohort of 304 lean and 283 obese children to assess a potential association with early onset obesity and blood pressure and evaluated the effect of this SNP on metabolic parameters in a smaller subset.The allele frequency of -803 G>A was similar in obese compared to lean subjects (0.159 vs. 0.191, P=0.318). We did not detect an association of the variant with adiposity parameters nor with parameters of glucose and lipid metabolism or blood pressure in quantitative analyses.Our study revealed that the promoter polymorphism -803 G>A in RBP4 is not associated with BMI, metabolic parameters or blood pressure in Caucasian children. |
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Authors:
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D Friebe; P Kovacs; M Neef; S Blüher; D Schleinitz; W Kiess; A Körner |
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Publication Detail:
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Type: Journal Article Date: 2011-11-08 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 119 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 628-32 Citation Subset: IM |
Copyright Information:
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© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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University Hospital for Children & Adolescents. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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