| Promiscuous anaerobes: new and unconventional metabolism in methanogenic archaea. | |
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MedLine Citation:
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PMID: 18096851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of an oxygenated atmosphere on earth resulted in the polarization of life into two major groups, those that could live in the presence of oxygen and those that could not-the aerobes and the anaerobes. The evolution of aerobes from the earliest anaerobic prokaryotes resulted in a variety of metabolic adaptations. Many of these adaptations center on the need to sustain oxygen-sensitive reactions and cofactors to function in the new oxygen-containing atmosphere. Still other metabolic pathways that were not sensitive to oxygen also diverged. This is likely due to the physical separation of the organisms, based on their ability to live in the presence of oxygen, which allowed for the independent evolution of the pathways. Through the study of metabolic pathways in anaerobes and comparison to the more established pathways from aerobes, insight into metabolic evolution can be gained. This, in turn, can allow for extra- polation to those metabolic pathways occurring in the Last Universal Common Ancestor (LUCA). Some of the unique and uncanonical metabolic pathways that have been identified in the archaea with emphasis on the biochemistry of an obligate anaerobic methanogen, Methanocaldococcus jannaschii are reviewed. |
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Authors:
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Laura L Grochowski; Robert H White |
Publication Detail:
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Type: Journal Article; Review Date: 2007-12-20 |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1125 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 190-214 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Amino Acids / metabolism Anaerobiosis Methanococcaceae / metabolism* Nucleosides / biosynthesis Nucleotides / biosynthesis Polyamines / metabolism Pyrimidines / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Nucleosides; 0/Nucleotides; 0/Polyamines; 0/Pyrimidines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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