Document Detail

Promiscuous anaerobes: new and unconventional metabolism in methanogenic archaea.
MedLine Citation:
PMID:  18096851     Owner:  NLM     Status:  MEDLINE    
The development of an oxygenated atmosphere on earth resulted in the polarization of life into two major groups, those that could live in the presence of oxygen and those that could not-the aerobes and the anaerobes. The evolution of aerobes from the earliest anaerobic prokaryotes resulted in a variety of metabolic adaptations. Many of these adaptations center on the need to sustain oxygen-sensitive reactions and cofactors to function in the new oxygen-containing atmosphere. Still other metabolic pathways that were not sensitive to oxygen also diverged. This is likely due to the physical separation of the organisms, based on their ability to live in the presence of oxygen, which allowed for the independent evolution of the pathways. Through the study of metabolic pathways in anaerobes and comparison to the more established pathways from aerobes, insight into metabolic evolution can be gained. This, in turn, can allow for extra- polation to those metabolic pathways occurring in the Last Universal Common Ancestor (LUCA). Some of the unique and uncanonical metabolic pathways that have been identified in the archaea with emphasis on the biochemistry of an obligate anaerobic methanogen, Methanocaldococcus jannaschii are reviewed.
Laura L Grochowski; Robert H White
Publication Detail:
Type:  Journal Article; Review     Date:  2007-12-20
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1125     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-214     Citation Subset:  IM    
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
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MeSH Terms
Amino Acids / metabolism
Methanococcaceae / metabolism*
Nucleosides / biosynthesis
Nucleotides / biosynthesis
Polyamines / metabolism
Pyrimidines / biosynthesis
Reg. No./Substance:
0/Amino Acids; 0/Nucleosides; 0/Nucleotides; 0/Polyamines; 0/Pyrimidines

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