Document Detail

Prolymphocytoid transformation of follicular lymphoma with coexpression of CD5 and CD10.
MedLine Citation:
PMID:  16396778     Owner:  NLM     Status:  MEDLINE    
Histologic transformation of follicular lymphoma is usually to a diffuse large B-cell lymphoma. We present a rare example of a histologic transformation of follicular lymphoma manifested by prolymphocytoid morphology and an unusual immunophenotype characterized by coexpression of CD5 and CD10. The transformed prolymphocytoid lymphoma was positive for CD5 and CD10 antigens by both flow cytometry and immunohistochemistry. The case also expressed bcl-2 and bcl-6 proteins, and exhibited t(14;18), consistent with derivation from a pre-existing follicular lymphoma. Polymerase chain reaction analysis of the immunoglobulin kappa light chain genes derived from the follicular lymphoma and prolymphocytoid lymphoma showed identical rearranged bands, suggesting clonal identity of the two neoplasms. The basis for coexpression of CD5 and CD10 remains unclear. Because the preceding low-grade follicular lymphoma was positive only for CD10 and did not express CD5, CD5 expression appears to be an acquired phenomenon accompanying the process of histologic transformation in this particular case. Prolymphocytoid transformation, similar to other histologic forms of transformation of follicular lymphoma, appears to accompany clinical progression of disease.
Sean K Lau; Lawrence M Weiss; Yibin Zhang; Qin Huang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  47     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-01-06     Completed Date:  2006-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-7     Citation Subset:  IM    
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
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MeSH Terms
Antigens, CD5 / biosynthesis*,  immunology
Cell Transformation, Neoplastic / immunology,  pathology*
Disease Progression
Fatal Outcome
Leukemia, Prolymphocytic / immunology,  pathology*
Lymphoma, Follicular / immunology,  pathology*,  therapy
Neoplasms, Second Primary / immunology,  pathology*,  therapy
Neprilysin / biosynthesis*,  immunology
Remission Induction
Treatment Failure
Reg. No./Substance:
0/Antigens, CD5; EC

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