Document Detail


Prolyl carboxypeptidase and its inhibitors in metabolism.
MedLine Citation:
PMID:  23245768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proopiomelanocortin (POMC)-expressing neurons in the hypothalamus integrate a variety of central and peripheral metabolic inputs, and regulate energy homeostasis by controlling energy expenditure and food intake. To accomplish this, a precise balance of production and degradation of α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide and product of the POMC gene, in the hypothalamus, is crucial. Prolyl carboxypeptidase (PRCP) is a key enzyme that degrades α-MSH to an inactive form unable to inhibit food intake. Because it represents a new therapeutic target for the treatment of metabolic disorders, such as obesity and diabetes, efforts have been made to generate potent, brain-penetrant PRCP inhibitors. Here, we discuss the role of PRCP on energy metabolism and the development of PRCP inhibitors.
Authors:
Jin Kwon Jeong; Sabrina Diano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-12
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  24     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-20     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aminopeptidases / antagonists & inhibitors*,  metabolism*
Eating / drug effects
Enzyme Inhibitors / pharmacology
Humans
Hypothalamus / drug effects,  metabolism
Pro-Opiomelanocortin / metabolism
Grant Support
ID/Acronym/Agency:
DK 084065/DK/NIDDK NIH HHS; R01 DK084065/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 66796-54-1/Pro-Opiomelanocortin; EC 3.4.11.-/Aminopeptidases; EC 3.4.11.5/prolyl aminopeptidase
Comments/Corrections

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