| Prolonging GnRH-agonist to achieve ovarian suppression does not compromise the results of a long protocol. | |
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MedLine Citation:
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PMID: 21763059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: In the long gonadotropin-releasing hormone agonist (GnRHa) protocols, stimulation is delayed until complete pituitary-ovarian suppression has been achieved, which usually takes a minimum of 10 days. In women who do not achieve timely suppression we set out to evaluate if prolonging GnRHa affects the results of the IVF process. STUDY DESIGN: We analyzed cycle and pregnancy outcome in 506 consecutive women undergoing IVF-ET after a standardized long GnRHa protocol, according to the time required to achieve ovarian suppression (i.e. estradiol<40pg/mL and no follicle >6mm at ultrasound). RESULTS: Suppression was obtained after 14 GnRHa days in 383 (75.70%) women (Group 1) and 123 (24.30%) women (Group 2) required a mean±SD (range) of 10±4 (7-28) additional days to achieve complete suppression. Both groups were comparable for baseline clinical and biological characteristics. The rate of cancelled cycles due to poor ovarian response, the number of the oocytes retrieved, fertilization rates, the number and quality of the embryos cultured and transferred were similar in both groups, as well as the pregnancy, implantation and live birth rates. In Group 2, receiver-operator characteristics analysis showed that the probability of pregnancy was not related to the duration of GnRHa treatment. CONCLUSIONS: In a standardized long GnRHa protocol, prolonging desensitization to achieve complete ovarian suppression does not affect the outcome. |
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Authors:
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Lionel Dessolle; Delphine Ferrier; Agnès Colombel; Thomas Fréour; Miguel Jean; Paul Barrière |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-13 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: - ISSN: 1872-7654 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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CHU Nantes, Service de médecine et biologie de la reproduction, Centre Hospitalier universitaire de Nantes, 38, Bd Jean Monnet, 44093 Nantes Cedex 1, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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