Document Detail

Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens).
MedLine Citation:
PMID:  19906819     Owner:  NLM     Status:  MEDLINE    
Botanicals have numerous health benefits. Here, we used the Mexican fruit fly to screen 14 compounds and botanicals for their prolongevity effects and found an oregano and cranberry mixture (OC) improved survival. We then evaluated prolongevity effects of OC within the context of diet composition. Individual flies were fed 0%, 1%, or 2% OC in one of the three diets containing sugar and yeast extract (SY) at a ratio of 3:1, 9:1, or 24:1. We found that prolongevity effects of OC depended upon dose, gender, and diet composition. The greatest increase in longevity was observed in females fed the SY24:1 diet with 2% OC compared to the non-supplemented diet. OC did not reduce egg laying and, hence, did not compromise fecundity under any dietary condition tested here. This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender.
Sige Zou; James R Carey; Pablo Liedo; Donald K Ingram; Binbing Yu; Reza Ghaedian
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2009-11-11
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  65     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-23     Completed Date:  2010-01-15     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  AIM; IM    
Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
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MeSH Terms
Appetitive Behavior / physiology*
Longevity / drug effects*,  physiology
Plant Extracts / pharmacology*
Tephritidae / growth & development*
Vaccinium macrocarpon*
Grant Support
P01-AG022500-01/AG/NIA NIH HHS; P01-AG08761-10/AG/NIA NIH HHS
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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