Document Detail

Prolonged vasodilation following fatiguing exercise of dog skeletal muscle.
MedLine Citation:
PMID:  1147054     Owner:  NLM     Status:  MEDLINE    
Prolonged vasodilation follows 20- and 60-min periods of stimulation (4 twitches/s) of dog skeletal muscle with blood flow held constant at 23 plus or minus 2 ml/100 g per min. During stimulation isometric tension development fell 61 plus or minus 3%, and we have operationally defined this as fatiguing exercise. During stimulation vasodilation was maximum. Following stimulation vascular resistance returned to control with average half-times of 6.9 plus or minus 0.6 and 5.8 plus or minus 0.4 min after 20 and 60 min of stimulation, respectively. This prolonged vascular recovery following fatiguing exercise is an order of magnitude slower than vascular recovery following less severe exercise. The pressor response to an intra-arterial bolus of angiotensin (0.5 mug) is not depressed during prolonged vasodilation. Prolonged vasodilation does not appear to be closely linked to changes in tissue oxygen consumption. In addition, the changes in resistance can be dissociated from changes in K+, osmolality, and lactate production following fatiguing exercise. We conclude that prolonged vasodilation following fatiguing exercise is caused by a metabolic vasodilator substance which is yet to be identified.
M L Morganroth; D E Mohrman; H V Sparks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM; S    
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MeSH Terms
Angiotensin II / pharmacology
Lactates / blood
Muscle Contraction* / drug effects
Muscles / blood supply*,  metabolism
Osmolar Concentration
Oxygen / blood
Oxygen Consumption
Physical Exertion*
Potassium / blood
Regional Blood Flow
Time Factors
Vascular Resistance / drug effects
Vasomotor System / physiology*
Reg. No./Substance:
0/Lactates; 11128-99-7/Angiotensin II; 7440-09-7/Potassium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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