| Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions. | |
| | |
MedLine Citation:
|
PMID: 7591335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The efficacy and side effects of the combination therapy of thiazide and furosemide administered to patients with refractory heart failure, for a prolonged period of time, were assessed. Thirty-two patients were hospitalized during the years 1985-1991. Left heart failure (left ventricular ejection fraction (LVEF = 22.4% +/- 6.6%) was present in 26 patients, right heart failure in 3 patients, chronic renal failure, cirrhosis and bilateral pleural effusion were present each in one patient. Chlorothiazide 0.5 g daily was added to conventional therapy. Patients were monitored closely during hospitalization and later as outpatients. During hospitalization, addition of chlorothiazide caused a reduction of 4.8 +/- 4.0 kg in patients' weight, serum potassium decreased from 4.4 +/- 0.6 to 4.0 +/- 0.5 mmol/l (P < 0.005) and serum sodium from 139.0 +/- 4.7 to 136.8 +/- 5.5 mmol/l (P < 0.05). The duration of the combined therapy was 17.2 +/- 19.1 months. Thirteen patients had short treatment (1.6 +/- 0.8 months) and 19 patients had prolonged treatment (26.5 +/- 19.0 months). No specific characteristics distinguished patients in both groups. Thiazides were discontinued in 19 patients, 10 of which had side effects. In only 5 of the 19 patients treated for the prolonged period had thiazides to be discontinued because of side effects. Addition of thiazides to furosemide is efficacious in severe heart failure. The combination should be started during hospitalization. Many patients can be maintained on this combination for a prolonged period of time on an ambulatory basis. |
| | |
Authors:
|
M Mouallem; I Brif; H Mayan; Z Farfel |
Related Documents
:
|
15716285 - Soluble cd40 ligand in acute and chronic heart failure. 19732315 - Heart rate increment analysis is not effective for sleep-disordered breathing screening... 6499855 - Permanent cardiac pacing in congenital heart disease: a follow-up study of 20 patients. 21447965 - Increased s-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with c... 3878905 - Bone gla protein in predialysis chronic renal failure. effects of 1,25(oh)2d3 administr... 8986965 - Immunoglobulin g subclass measurements in recurrent aphthous stomatitis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 50 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1995 Jun |
Date Detail:
|
Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
|
Department of Medicine E, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Cardiomyopathy, Dilated / drug therapy, physiopathology Chlorothiazide / administration & dosage*, adverse effects Diuretics / administration & dosage*, adverse effects Drug Administration Schedule Drug Therapy, Combination Female Furosemide / administration & dosage*, adverse effects Heart Failure / drug therapy*, physiopathology Hemodynamics / drug effects*, physiology Humans Male Middle Aged Myocardial Ischemia / drug therapy, physiopathology Potassium / blood Rheumatic Heart Disease / drug therapy, physiopathology Sodium / blood Sodium Chloride Symporter Inhibitors / administration & dosage*, adverse effects Stroke Volume / drug effects, physiology Treatment Outcome Ventricular Function, Left / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 54-31-9/Furosemide; 58-94-6/Chlorothiazide; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biventricular thrombi in diabetic nephrotic syndrome complicated by cerebral embolism.
Next Document: Protein synthesis in the heart in vivo, its measurement and patho-physiological alterations.