| Prolonged swimming exercise training induce hypophosphatemic osteopenia in stroke-prone spontaneously hypertensive rats (SHRSP). | |
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MedLine Citation:
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PMID: 11204874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stroke-prone spontaneously hypertensive rats (SHRSP) induce spontaneous osteoporosis. To elucidate the specific characteristics of bone metabolism, the SHRSP was compared with age matched Wistar-Kyoto (WKY) rats. We investigated the effects of prolonged swimming exercise training on bone mineral density (BMD) and metabolism in the SHRSP. Seven-week-old male SHRSP and WKY were divided into three groups; the sedentary control WKY group (n = 6, WKY), the sedentary control SHRSP group (n = 6, SP) and the swimming exercise training SHRSP group (n = 6, SWIM) (in pool with 60 min./day, 5 days/week for 12 weeks). The femoral BMD, bone mineral content (BMC), strength, Ca and P contents (%) of SHRSP were approximately 17, 27, 25, 20 and 9%, respectively, lower than that of WKY (p < 0.001). Serum alkaline phosphatase (AlP) had not changed between both of SP and WKY, but tartrate-resistant acid phosphatase (TrAcP) of SP approximately 3-fold higher than that of WKY (p < 0.05). Both serum calcium (Ca) and intact parathyroid hormone (i-PTH) were similar between SP and WKY. However, serum phosphate (P) of SP was approximately 18% lower than that of WKY (N.S.). These results suggested that SHRSP induces osteopenia by the bone turnover of the promoted osteoclast activity with disturbed phosphate homeostasis. On the other hand, the femoral BMD and strength were approximately 7% and 20%, respectively, decreased in the SWIM (p < 0.001), and femoral bone Ca and P contents (%) were also approximately 11% and 14%, respectively, lower than that of SP (p < 0.001). There were no significant difference between SWIM and SP on serum Ca, but serum P of SWIM was significantly lower than that of SP (p < 0.05). These results suggested that the prolonged swimming exercise training in the SHRSP induces more cruelly hypophosphatemia, and leading to osteopenia eventually. We conclude that SHRSP induces osteopenia with disturbance of phosphate homeostasis, and the prolonged swimming exercise in the SHRSP might deteriorate hypophosphatemia and osteopenia. |
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Authors:
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C S Kim; D Nakajima; C Y Yang; T W Oh; S Igawa; M Miyazaki; H Fukuoka; F Ohta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of physiological anthropology and applied human science Volume: 19 ISSN: 1345-3475 ISO Abbreviation: J Physiol Anthropol Appl Human Sci Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-05 Completed Date: 2001-03-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100930389 Medline TA: J Physiol Anthropol Appl Human Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: IM |
Affiliation:
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Department of Sports Sciences, School of Human Sciences, Waseda University. chang@human.waseda.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density Bone Diseases, Metabolic / etiology* Disease Models, Animal Hypophosphatemia / etiology* Male Physical Conditioning, Animal / adverse effects* Rats Rats, Inbred SHR Rats, Inbred WKY Swimming / physiology* |
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