Document Detail

Prolonged suxamethonium infusion during nitrous oxide anaesthesia supplemented with halothane or fentanyl.
MedLine Citation:
PMID:  6313024     Owner:  NLM     Status:  MEDLINE    
The neuromuscular blockade produced by a prolonged infusion of suxamethonium was studied using train-of-four stimulation in 40 patients receiving either halothane-nitrous oxide or fentanyl-nitrous oxide anaesthesia. Initially, a depolarizing (phase I) block was observed in all patients followed by phase II block which was associated with tachyphylaxis to suxamethonium; the latter changes occurring more rapidly in the halothane group. Infusions were continued for more than 150 min in 17 patients and there was a late decrease in suxamethonium requirement in those who received halothane, but not fentanyl. Ten minutes after the suxamethonium infusion was stopped, most patients received neostigmine which was followed by rapid recovery of neuromuscular transmission.
M E Futter; F Donati; D R Bevan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  55     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  947-53     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General*
Infusions, Parenteral
Middle Aged
Neuromuscular Junction / drug effects
Nitrous Oxide*
Succinylcholine / administration & dosage*
Synaptic Transmission / drug effects
Time Factors
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 306-40-1/Succinylcholine; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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