Document Detail


Prolonged survival of rat hindlimb allografts following short-course FK506 and mycophenolate mofetil combination therapy.
MedLine Citation:
PMID:  15880483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunosuppressive effect of combined therapy using FK506 and mycophenolate mofetil (MMF) was studied in rat limb allotransplantation. Dark Agouti rat donor hindlimbs were orthotopically transplanted into Lewis rat recipients. In total, 38 models of transplantation were performed and divided into 8 groups that were treated individually or in combination with FK506 + MMF therapy. Animals were immunosuppressed for 28 days and then observed for up to 140 days. Graft rejection was evaluated both macroscopically and histologically. Survival times for rat limb allotransplants receiving combination FK506 + MMF therapy were significantly longer than with FK506 or MMF monotherapy, and this was achieved without serious side effects. A histopathological study demonstrated a significantly lower level of rejection with FK506 + MMF combination treatment compared to groups receiving FK506 or MMF monotherapy. Combined FK506 + MMF treatment can prolong the survival of rat limb allografts.
Authors:
You-Xin Song; Keiichi Muramatsu; Yoko Kurokawa; Toshihiko Taguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microsurgery     Volume:  25     ISSN:  0738-1085     ISO Abbreviation:  Microsurgery     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-30     Completed Date:  2005-10-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-9     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc.
Affiliation:
Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Administration Schedule
Drug Therapy, Combination
Graft Rejection / pathology,  prevention & control*
Graft Survival / drug effects*
Hindlimb / pathology,  transplantation*
Immunosuppressive Agents / administration & dosage*
Mycophenolic Acid / administration & dosage,  analogs & derivatives*
Rats
Rats, Inbred Strains
Tacrolimus / administration & dosage*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

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