| Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. | |
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MedLine Citation:
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PMID: 9252483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise. |
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Authors:
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T Rohde; D A MacLean; E A Richter; B Kiens; B K Pedersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 273 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E85-91 Citation Subset: IM; S |
Affiliation:
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Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, Copenhagen N, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / blood Amino Acids, Branched-Chain / pharmacology* Analysis of Variance Cytokines / blood* Epinephrine / blood Exercise / physiology* Exercise Test Food, Fortified Humans Interleukin-1 / blood Interleukin-6 / blood* Killer Cells, Natural / drug effects, immunology* Leukocyte Count Lymphocyte Activation* Lymphocyte Count Male Muscle, Skeletal / physiology* Norepinephrine / blood Reference Values Time Factors Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
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