Document Detail

Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6.
MedLine Citation:
PMID:  9252483     Owner:  NLM     Status:  MEDLINE    
To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.
T Rohde; D A MacLean; E A Richter; B Kiens; B K Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-03     Completed Date:  1997-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E85-91     Citation Subset:  IM; S    
Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, Copenhagen N, Denmark.
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MeSH Terms
Amino Acids / blood
Amino Acids, Branched-Chain / pharmacology*
Analysis of Variance
Cytokines / blood*
Epinephrine / blood
Exercise / physiology*
Exercise Test
Food, Fortified
Interleukin-1 / blood
Interleukin-6 / blood*
Killer Cells, Natural / drug effects,  immunology*
Leukocyte Count
Lymphocyte Activation*
Lymphocyte Count
Muscle, Skeletal / physiology*
Norepinephrine / blood
Reference Values
Time Factors
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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