Document Detail

Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells.
MedLine Citation:
PMID:  17727850     Owner:  NLM     Status:  MEDLINE    
The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like endometriotic cell line with tumor necrosis factor alpha stimulation for 30 days induced partial methylation in the promoter region of PR-B with concomitant reduction of PR-B expression.
Yan Wu; Anna Starzinski-Powitz; Sun-Wei Guo
Publication Detail:
Type:  Journal Article     Date:  2007-08-29
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-01     Completed Date:  2008-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  IM    
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
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MeSH Terms
Cell Line
DNA Methylation*
Endometriosis / genetics,  metabolism*
Endometrium / metabolism*
Epithelial Cells / metabolism*
Promoter Regions, Genetic*
Receptors, Progesterone / genetics,  metabolism*
Stromal Cells / metabolism
Time Factors
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Receptors, Progesterone; 0/Tumor Necrosis Factor-alpha; 0/progesterone receptor B

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