Document Detail


Prolonged serum levodopa levels with controlled-release carbidopa-levodopa in the treatment of Parkinson's disease.
MedLine Citation:
PMID:  3276299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty parkinsonian patients (Hoehn and Yahr scale, I through III) were treated with controlled-release carbidopa-levodopa (CR-2 or CR-3) and standard carbidopa-levodopa (Sinemet, 25 mg/100 mg) in a double-blind, crossover pharmacokinetic and clinical efficacy study. The controlled-release agents had a slower rise to peak plasma values and flatter pharmacokinetic curves than did the standard. The area under the curve for CR-3 was significantly increased by 55.5% as compared with standard agent and by 84.2% as compared with CR-2. No differences in clinical efficacy were found between controlled-release agents and the standard agent for this group of parkinsonian patients with mild to moderate severity. The dissociation between the prolonged serum levodopa levels and unimproved clinical efficacy may have resulted from the absence of patients with prominent motor fluctuations and/or substantial serum levodopa variability that was especially prominent with CR-3.
Authors:
J T Hutton; J W Albrecht; G C Román; M T Kopetzky
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  45     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-01-27     Completed Date:  1988-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical and Surgical Neurology, Texas Tech University Health Sciences Center, Lubbock 79430.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carbidopa / administration & dosage*,  pharmacokinetics
Clinical Trials as Topic
Delayed-Action Preparations
Double-Blind Method
Drug Combinations
Female
Humans
Levodopa / administration & dosage,  blood*,  pharmacokinetics
Male
Middle Aged
Parkinson Disease / blood*,  drug therapy
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Combinations; 0/Levodopa; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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