| Prolonged separation delays wound healing in monogamous California mice, Peromyscus californicus, but not in polygynous white-footed mice, P. leucopus. | |
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MedLine Citation:
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PMID: 16616944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Social interactions are often stressful, but under certain circumstances, they may be beneficial for health and well-being. In a previous study, wound healing was slowed after mate separation (2 days) in monogamous California mice, Peromyscus californicus, but not polygynous white-footed mice, P. leucopus. Although these results indicate that positive social interaction is critical for immune activity in some species, the extent to which such social effects are enduring remains unspecified. The goal of the present experiments was to determine whether a period representing approximately 20% of expected adult lifespan of these species in the wild (8 weeks) would affect wound healing. Because our experimental design required that the same animals were wounded twice, we were also able to determine the extent to which wound healing is repeatable. Wound healing remained delayed after 8 weeks of separation in P. californicus, and healing scores were not correlated between first and second wounds within individuals. In P. leucopus however, housing conditions did not influence wound healing, but first and second wound healings were correlated indicating repeatability. In sum, our results suggest that positive social interactions may be important for promoting immune activity in some species. |
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Authors:
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Lynn B Martin; Erica R Glasper; Randy J Nelson; A Courtney Devries |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-03-06 |
Journal Detail:
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Title: Physiology & behavior Volume: 87 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-02 Completed Date: 2006-07-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 837-41 Citation Subset: IM |
Affiliation:
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Department of Psychology and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA. lmartin@mail.psy.ohio-state.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Interpersonal Relations* Male Mice Pair Bond Peromyscus / physiology*, psychology* Species Specificity Time Factors Wound Healing / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH 57535/MH/NIMH NIH HHS; MH 66144/MH/NIMH NIH HHS; P30NS045758/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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