Document Detail

Prolonged pulseless perfusion in unanesthetized calves.
MedLine Citation:
PMID:  985069     Owner:  NLM     Status:  MEDLINE    
Nonpulsatile left ventricular (LV) bypass was achieved in nine alert, active calves for periods of up to two weeks using a centrifugal blood pump. Data were compared to prebypass control values and to results obtained from seven calves that underwent nonthoracotomy, retrograde LV cannulation, and pulsatile bypass for up to 35 days. Nonpulsatile flow produced an increase in heart rate of 20% (P less than .05) and an increase in aortic pressure of 10% (P less than .05). Cardiac output and systemic vascular resistance were similar in both groups for three days; thereafter, vascular resistance decreased as cardiac output progressively increased. Serum renin, lactate, and pyruvate values remained normal; creatinine clearances were not significantly different than control values, and there were no significant changes in body weight. These data indicate no untoward effects as a result of prolonged pulseless perfusion.
G G Johnston; F Hammill; U Marzec; D Gerard; K Johansen; R B Dilley; E F Bernstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  111     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1225-30     Citation Subset:  AIM; IM    
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MeSH Terms
Aorta / physiology
Blood Pressure
Blood Urea Nitrogen
Body Weight
Cardiac Output
Cardiopulmonary Bypass / methods*
Creatinine / blood
Heart Rate
Heart Ventricles
Heart-Lung Machine
Kidney / metabolism
Lactates / blood
Pyruvates / blood
Renin / blood
Time Factors
Vascular Resistance
Reg. No./Substance:
0/Lactates; 0/Pyruvates; 60-27-5/Creatinine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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