| Prolonged period of global ischemia causes no change in the GTP-binding proteins in the isolated perfused rat heart. | |
| | |
MedLine Citation:
|
PMID: 1666054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The response of the beta-adrenoceptor transduction system to global ischemia for 40 min was investigated in isolated working heart of rat. The enhancement of beta-adrenoceptors was not observed in the ischemic myocardium. A depression of forskolin-stimulated adenylate cyclase enzyme occurred with global ischemia, but no change in Gs or Gi2 was detected. Thus, the present in vitro ischemic heart model may not necessarily reflect the identical milieu induced by the in vivo myocardial ischemia. |
| | |
Authors:
|
K Tobise; M Abe; S Onodera |
Related Documents
:
|
23476044 - Coronary wave energy: a novel predictor of functional recovery after myocardial infarct... 10835514 - Is apoptosis a diagnostic marker of acute myocardial infarction? 9395164 - Comparison of the effects of regional ischemia and hyperkalemia on the membrane action ... 2982344 - Experimental myocardial ischemia. differential injury of mitochondrial subpopulations. 14643794 - Regulation of myocardial triacylglycerol synthesis and metabolism. 20542784 - A european multicentre, randomised study of the mar-tyn cobalt chromium tin-coated sten... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
|
Title: European journal of pharmacology Volume: 208 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-04-21 Completed Date: 1992-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 183-7 Citation Subset: IM |
Affiliation:
|
First Department of Internal Medicine, Asahikawa Medical College, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenylate Cyclase
/
metabolism Animals Coronary Disease / metabolism*, physiopathology GTP-Binding Proteins / metabolism* Macromolecular Substances Male Myocardium / enzymology, metabolism Perfusion Rats Rats, Inbred Strains Receptors, Adrenergic, beta / metabolism Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Macromolecular Substances; 0/Receptors, Adrenergic, beta; EC 3.6.1.-/GTP-Binding Proteins; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
Next Document: Enhanced frequency of spontaneous B cell lines from Epstein-Barr virus (EBV) seropositive donors 80 ...