Document Detail


Prolonged period of global ischemia causes no change in the GTP-binding proteins in the isolated perfused rat heart.
MedLine Citation:
PMID:  1666054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The response of the beta-adrenoceptor transduction system to global ischemia for 40 min was investigated in isolated working heart of rat. The enhancement of beta-adrenoceptors was not observed in the ischemic myocardium. A depression of forskolin-stimulated adenylate cyclase enzyme occurred with global ischemia, but no change in Gs or Gi2 was detected. Thus, the present in vitro ischemic heart model may not necessarily reflect the identical milieu induced by the in vivo myocardial ischemia.
Authors:
K Tobise; M Abe; S Onodera
Related Documents :
1725914 - The effect of verapamil on major events in patients with exercise-induced ischemia reco...
24505394 - 1h-nmr-based metabolic analysis of human serum reveals novel markers of myocardial ener...
23152364 - Biodegradable versus durable polymer drug eluting stents in coronary artery disease: in...
3162034 - The effect of short term normothermic global ischemia and acidosis on cardiac myofibril...
1980634 - Hemodynamic and neurohumoral effects of ibopamine in patients with chronic congestive h...
23437344 - Snps identified as modulators of ecg traits in the general population do not markedly a...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  208     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Asahikawa Medical College, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / metabolism
Animals
Coronary Disease / metabolism*,  physiopathology
GTP-Binding Proteins / metabolism*
Macromolecular Substances
Male
Myocardium / enzymology,  metabolism
Perfusion
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta / metabolism
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Macromolecular Substances; 0/Receptors, Adrenergic, beta; EC 3.6.1.-/GTP-Binding Proteins; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
Next Document:  Enhanced frequency of spontaneous B cell lines from Epstein-Barr virus (EBV) seropositive donors 80 ...