Document Detail

Prolonged period of global ischemia causes no change in the GTP-binding proteins in the isolated perfused rat heart.
MedLine Citation:
PMID:  1666054     Owner:  NLM     Status:  MEDLINE    
The response of the beta-adrenoceptor transduction system to global ischemia for 40 min was investigated in isolated working heart of rat. The enhancement of beta-adrenoceptors was not observed in the ischemic myocardium. A depression of forskolin-stimulated adenylate cyclase enzyme occurred with global ischemia, but no change in Gs or Gi2 was detected. Thus, the present in vitro ischemic heart model may not necessarily reflect the identical milieu induced by the in vivo myocardial ischemia.
K Tobise; M Abe; S Onodera
Related Documents :
23476044 - Coronary wave energy: a novel predictor of functional recovery after myocardial infarct...
10835514 - Is apoptosis a diagnostic marker of acute myocardial infarction?
9395164 - Comparison of the effects of regional ischemia and hyperkalemia on the membrane action ...
2982344 - Experimental myocardial ischemia. differential injury of mitochondrial subpopulations.
14643794 - Regulation of myocardial triacylglycerol synthesis and metabolism.
20542784 - A european multicentre, randomised study of the mar-tyn cobalt chromium tin-coated sten...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  208     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
First Department of Internal Medicine, Asahikawa Medical College, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenylate Cyclase / metabolism
Coronary Disease / metabolism*,  physiopathology
GTP-Binding Proteins / metabolism*
Macromolecular Substances
Myocardium / enzymology,  metabolism
Rats, Inbred Strains
Receptors, Adrenergic, beta / metabolism
Signal Transduction / physiology
Reg. No./Substance:
0/Macromolecular Substances; 0/Receptors, Adrenergic, beta; EC 3.6.1.-/GTP-Binding Proteins; EC Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
Next Document:  Enhanced frequency of spontaneous B cell lines from Epstein-Barr virus (EBV) seropositive donors 80 ...