Document Detail

Prolonged period of global ischemia causes no change in the GTP-binding proteins in the isolated perfused rat heart.
MedLine Citation:
PMID:  1666054     Owner:  NLM     Status:  MEDLINE    
The response of the beta-adrenoceptor transduction system to global ischemia for 40 min was investigated in isolated working heart of rat. The enhancement of beta-adrenoceptors was not observed in the ischemic myocardium. A depression of forskolin-stimulated adenylate cyclase enzyme occurred with global ischemia, but no change in Gs or Gi2 was detected. Thus, the present in vitro ischemic heart model may not necessarily reflect the identical milieu induced by the in vivo myocardial ischemia.
K Tobise; M Abe; S Onodera
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  208     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
First Department of Internal Medicine, Asahikawa Medical College, Japan.
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MeSH Terms
Adenylate Cyclase / metabolism
Coronary Disease / metabolism*,  physiopathology
GTP-Binding Proteins / metabolism*
Macromolecular Substances
Myocardium / enzymology,  metabolism
Rats, Inbred Strains
Receptors, Adrenergic, beta / metabolism
Signal Transduction / physiology
Reg. No./Substance:
0/Macromolecular Substances; 0/Receptors, Adrenergic, beta; EC 3.6.1.-/GTP-Binding Proteins; EC Cyclase

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