Document Detail

Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent.
MedLine Citation:
PMID:  12746791     Owner:  NLM     Status:  MEDLINE    
Treatment of neurocysticercosis with larvicidal agents is commonly complicated by seizures and transient neurologic deficits as a result of the host immune response to dying cysts. We report a case in which treatment with high-dose praziquantel resulted in prolonged perilesional edema requiring use of corticosteroids and corticosteroid-sparing agents for >1 year, suggesting a role for methotrexate in the management of this condition.
Paul B Keiser; Theodore E Nash
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2003-05-09
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  36     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-14     Completed Date:  2003-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e122-6     Citation Subset:  IM    
Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Albendazole / therapeutic use
Anthelmintics / therapeutic use*
Edema / drug therapy
Middle Aged
Neurocysticercosis / drug therapy*,  immunology
Praziquantel / therapeutic use*
Taenia solium / drug effects,  immunology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anthelmintics; 54965-21-8/Albendazole; 55268-74-1/Praziquantel; 59-05-2/Methotrexate

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