Document Detail

Prolonged norovirus shedding in infants <or=6 months of age with gastroenteritis.
MedLine Citation:
PMID:  17195705     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Noroviruses (NV) are one of the leading causes of gastroenteritis in young children; however, the duration of NV shedding in young children is not well known. METHODS: Fecal specimens were collected from children with acute gastroenteritis at a pediatric clinic during the period from November to December 2002 and tested for NV by reverse transcription-polymerase chain reaction. RESULTS: Of 71 children infected with NV, 60 (84.5%) were less than 3 years old. Among children aged <2 years and those aged 2 to 5 years, the duration of illness was longer (7 days versus 3.5 days, P = 0.0069), the maximum number of stools in a 24-hour period was greater (7 versus 3, P = 0.0078) and a 20-point severity score was higher (11 versus 8, P = 0.0031) in patients aged <2 years than in patients aged 2 to 5 years. Among the 23 children whose follow-up specimens were obtained, the median duration of NV shedding was 16 days (range, 5-47 days). Virus shedding for more than 2 weeks after onset was observed in 75% (6 of 8), 71.4% (5 of 7) and 25% (2 of 8) of children aged <1 year, 1 year and 2 to 3 years, respectively. Three infants aged <or=6 months continued to excrete NV for an extremely long period (more than 42, 44 and 47 days from onset) after recovery. CONCLUSION: Long-term virus shedding after the disappearance of clinical symptoms was observed. Caution should be exercised when handling the excrement of infants and young children infected with NV.
Toshio Murata; Noriko Katsushima; Katsumi Mizuta; Yasushi Muraki; Seiji Hongo; Yoko Matsuzaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  26     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata, Japan.
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MeSH Terms
Caliciviridae Infections / virology*
Child, Preschool
Feces / virology
Gastroenteritis / virology*
Norovirus / isolation & purification*
Reverse Transcriptase Polymerase Chain Reaction
Virus Shedding

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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