Document Detail

Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall.
MedLine Citation:
PMID:  9609349     Owner:  NLM     Status:  MEDLINE    
We investigated the morphological changes in the aorta due to reduced systemic pulse pressure in prolonged nonpulsatile left heart bypass (LHB). Nineteen adult goats were divided into 3 groups, the nonpulsatile group in which nonpulsatile LHB was conducted, the pulsatile group in which pulsatile LHB was conducted, and the control group used as the normal control. The average aortic pulse pressures were 12, 47, and 37 mm Hg, respectively. The descending aorta was subjected to morphological examination. In the nonpulsatile group, the wall was significantly thinner, and the volume ratio of smooth muscle cells (SMCs) was much lower. In terms of the SMC type classification, the proportion of SMCs with low activity and low contractility was higher, and the cell density of the SMCs was increased compared to those in the other groups. These results indicate that prolonged nonpulsatile LHB causes morphological atrophic changes in the aorta.
T Nishimura; E Tatsumi; S Takaichi; Y Taenaka; Y Wakisaka; T Nakatani; T Masuzawa; Y Takewa; M Nakamura; S Endo; M Nakata; H Takano
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  22     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-09     Completed Date:  1998-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
Department of Artificial Organs, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.
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MeSH Terms
Aorta, Thoracic / pathology*,  ultrastructure
Blood Flow Velocity / physiology
Cell Count
Cell Wall / pathology,  ultrastructure
Heart Bypass, Left*
Muscle Contraction / physiology
Muscle, Smooth, Vascular / physiology*,  ultrastructure
Pulsatile Flow

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