Document Detail

Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling.
MedLine Citation:
PMID:  7774679     Owner:  NLM     Status:  MEDLINE    
In neonatal rat ventricular myocytes prolonged incubation with 1 microM neuropeptide Y (2 h-48 h) increased beta-adrenoceptor density 16-24% (n = 4--8, all p < 0.05), an effect prevented by pertussis toxin pretreatment. Prolonged incubation with neuropeptide Y had no effect on adenylycylclase activity stimulated by 5'-guanylylimidodiphosphate or (-)-isoprenaline, probably because of a neuropeptide Y-induced decrease in affinity of the beta-adrenoceptor for agonist. Thus, chronic incubation with an inhibitory agonist does not inevitably lead to supersensitivity of the adenylylcyclase pathway.
K J Rocha-Singh; R Matsuo; J S Karliner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  288     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-11     Completed Date:  1995-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Cardiology Section (111C), Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
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MeSH Terms
Adenylate Cyclase / metabolism
Animals, Newborn
Cells, Cultured
Guanylyl Imidodiphosphate / pharmacology
Heart Ventricles / drug effects,  enzymology
Isoproterenol / pharmacology
Neuropeptide Y / pharmacology*
Radioligand Assay
Receptors, Adrenergic, beta / drug effects*
Signal Transduction
Grant Support
Reg. No./Substance:
0/Neuropeptide Y; 0/Receptors, Adrenergic, beta; 34273-04-6/Guanylyl Imidodiphosphate; 7683-59-2/Isoproterenol; EC Cyclase

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