| Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling. | |
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MedLine Citation:
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PMID: 7774679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In neonatal rat ventricular myocytes prolonged incubation with 1 microM neuropeptide Y (2 h-48 h) increased beta-adrenoceptor density 16-24% (n = 4--8, all p < 0.05), an effect prevented by pertussis toxin pretreatment. Prolonged incubation with neuropeptide Y had no effect on adenylycylclase activity stimulated by 5'-guanylylimidodiphosphate or (-)-isoprenaline, probably because of a neuropeptide Y-induced decrease in affinity of the beta-adrenoceptor for agonist. Thus, chronic incubation with an inhibitory agonist does not inevitably lead to supersensitivity of the adenylylcyclase pathway. |
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Authors:
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K J Rocha-Singh; R Matsuo; J S Karliner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 288 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-07-11 Completed Date: 1995-07-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
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Cardiology Section (111C), Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Animals Animals, Newborn Cells, Cultured Guanylyl Imidodiphosphate / pharmacology Heart Ventricles / drug effects, enzymology Isoproterenol / pharmacology Neuropeptide Y / pharmacology* Radioligand Assay Rats Receptors, Adrenergic, beta / drug effects* Signal Transduction Up-Regulation* |
| Grant Support | |
ID/Acronym/Agency:
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HL 07507-02/HL/NHLBI NIH HHS; HL 25847/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Receptors, Adrenergic, beta; 34273-04-6/Guanylyl Imidodiphosphate; 7683-59-2/Isoproterenol; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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