Document Detail

Prolonged hypothermia due to olanzapine in the setting of renal failure: a case report and review of the literature.
MedLine Citation:
PMID:  24294486     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Temperature dysregulation is an infrequent but previously documented adverse effect of antipsychotic medications. The majority of documented cases involve durations of hypothermia of less than 24 h. We present the case of a patient on therapeutic olanzapine for bipolar disease with dehydration from gastroenteritis leading to acute kidney injury in the setting of stage III chronic kidney disease, who presented with severe hypothermia of 31.2°C (88.2°F). He required active rewarming in the intensive care unit for a total of 9 days. This is the second case report of prolonged hypothermia from olanzapine in the setting of kidney disease. Clinicians should be aware that patients with renal dysfunction may be at increased risk for prolonged hypothermia from olanzapine.
Ankit Kansagra; Sanket Patel; Susan Renee Wilcox
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Therapeutic advances in psychopharmacology     Volume:  3     ISSN:  2045-1253     ISO Abbreviation:  Ther Adv Psychopharmacol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-02     Completed Date:  2013-12-02     Revised Date:  2013-12-16    
Medline Journal Info:
Nlm Unique ID:  101555693     Medline TA:  Ther Adv Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  -    
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