| Prolonged gonadotropin-releasing hormone agonist therapy reduced expression of nitric oxide synthase in the endometrium of women with endometriosis and infertility. | |
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MedLine Citation:
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PMID: 16580392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether endometrial expression of endothelial nitric oxide synthase (eNOS) or inducible NOS (iNOS) protein in women with endometriosis-associated infertility is different from that in the fertile controls, whether GnRH agonist (GnRH-a) regulates the endometrial expression of NOS in women with endometriosis-associated infertility, and whether there is a correlation between serum E2 or P levels, and the endometrial expression of eNOS or iNOS. DESIGN: Prospective controlled study. SETTING: University hospital for reproductive medicine and gynecologic endocrinology. PATIENT(S): Thirty patients with endometriosis-associated infertility and 19 patients with carcinoma in situ of the cervix. INTERVENTION(S): Endometrial biopsy specimens and blood samples. MAIN OUTCOME MEASURE(S): Endometrial eNOS and iNOS protein relative levels and serum concentrations of E2 or P. RESULT(S): By Western blot analysis, iNOS was not detected, and a unique menstrual cycle-dependent expression of eNOS was observed. Eutopic endometrium in women with endometriosis-associated infertility before GnRH-a treatment showed higher levels of eNOS than that of the control group. After 3 months of GnRH-a therapy, eNOS levels in the endometrium were reduced. In addition, a significant positive correlation was found between serum E2 or P concentrations, and the endometrial expression of eNOS. CONCLUSION(S): The GnRH-a treatment attenuated the endometrial expression of eNOS in women with endometriosis-associated infertility. Endogenous ovarian steroids influence endometrial eNOS expression. |
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Authors:
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JianHua Wang; FuZhen Zhou; MinYue Dong; RuiJin Wu; YuLi Qian |
Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 85 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-05-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1037-44 Citation Subset: IM |
Affiliation:
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Department of Reproductive Endocrinology, Women's Hospital, The School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Endometriosis / drug therapy, enzymology* Endometrium / drug effects, enzymology* Female Gene Expression Regulation, Enzymologic / drug effects, physiology Gonadotropin-Releasing Hormone / administration & dosage*, agonists* Humans Infertility, Female / drug therapy, enzymology* Menstrual Cycle / drug effects, metabolism Nitric Oxide Synthase Type II / antagonists & inhibitors*, biosynthesis, genetics Nitric Oxide Synthase Type III / antagonists & inhibitors*, biosynthesis, genetics Prospective Studies |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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