Document Detail


Prolonged general anesthesia for experimental craniofacial surgery in fetal swine.
MedLine Citation:
PMID:  9100176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A protocol utilizing high preoperative doses of altrenogest (Regu-Mate) and a "balanced" general anesthesia regimen consisting of isoflurane at subanesthetic doses supplemented with intravenous doses of sodium thiopental was developed to prevent preterm labor, minimize intracranial fetal cerebral edema, and decrease postpartum mortality of fetal swine after undergoing complex in utero craniofacial procedures. A total of 20 fetal piglets at 75% gestation were exposed to prolonged (> 3 h) anesthesia conditions of which 7 piglets were randomly selected to undergo experimental craniofacial procedures consisting of periosteal stripping of frontal and parietal bone segments with/without extensive coronal suture fusion procedures. Neither sows nor piglets were lost to anesthetic complications during the initial laparotomy or subsequent cesarean delivery. None of the sows experienced uterine sepsis or underwent preterm labor. The overall survival rate for all piglets exposed to prolonged anesthesia conditions was 95% at 4 weeks and 45% at 11 weeks after surgery. The experimental group's survival was 85.7% at 4 weeks and 28.5% at 11 weeks after surgery.
Authors:
C D Sims; P E Butler; R Casanova; M A Randolph; M J Yaremchuk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  10     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    1997 Jan-Apr
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Affiliation:
Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General / methods*
Anesthetics, Inhalation / pharmacology
Animals
Craniofacial Abnormalities / mortality,  surgery*
Disease Models, Animal
Female
Fetus / surgery*
Isoflurane / pharmacology
Postoperative Care
Pregnancy
Progesterone Congeners / pharmacology
Swine
Time Factors
Trenbolone / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Progesterone Congeners; 10161-33-8/Trenbolone; 26675-46-7/Isoflurane; 850-52-2/altrenogest

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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