Document Detail

Prolonged exposure to one percent carbon monoxide causes a leucoencephalopathy in un-anaesthetised sheep.
MedLine Citation:
PMID:  11522368     Owner:  NLM     Status:  MEDLINE    
A total of 15 Levine-prepared adult un-anaesthetised sheep were exposed to 1% carbon monoxide (CO) in air for between 45 and 150 min. This exposure caused a reversible increase in blood carboxyhaemoglobin concentration and heart rate, and a similarly reversible decrease in electroencephalographic frequency and level of consciousness. sheep were either normotensive or slightly hypertensive. Sheep brains were subsequently examined for histopathological changes at either 5 or 14 days post- exposure. No dead neurons or apoptotic cells were seen, but most sheep given a prolonged exposure to CO had some axonal damage and associated gliosis. This damage was concentrated about necrotic micro-foci in the peri-ventricular white matter. These results suggest that a leucoencephalopathy is a primary consequence of acute and sub-acute CO toxicity.
D F Gorman; Y L Huang; C Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  165     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-10-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  97-107     Citation Subset:  IM    
Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
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MeSH Terms
Axons / drug effects
Brain / drug effects,  pathology
Brain Diseases / blood,  chemically induced*,  pathology
Carbon Monoxide / toxicity*
Carbon Monoxide Poisoning / blood,  pathology*
Carboxyhemoglobin / metabolism
Electroencephalography / drug effects
Gliosis / chemically induced
Heart Rate / drug effects
Leukoencephalopathy, Progressive Multifocal / blood,  chemically induced*,  pathology
Reg. No./Substance:
630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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