Document Detail


Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes.
MedLine Citation:
PMID:  12012074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise induces a post-exercise decline in the number of circulating lymphocytes. The aim of the present study was to investigate whether strenuous exercise induces lymphocyte apoptosis and generation of reactive oxygen species. Eleven healthy male subjects exercised for 2.5 h on a treadmill. Apoptotic lymphocytes were defined by being annexin positive and 7-aminoactinomycin-D negative. Measurement of F(2)-isoprostanes was used as a marker of oxidant stress in vivo. An increase (60%, P<0.05) in the percentage of apoptotic circulating lymphocytes was found 2 h post-exercise, whereas the total number of apoptotic cells did not change in relation to exercise. The concentration of plasma F(2)-isoprostanes increased approximately 1.6-fold in response to exercise, but declined towards pre-exercise values within the 1st h of recovery. The plasma concentrations of adrenaline, noradrenaline and cortisol increased during exercise. In conclusion, the results of the present study demonstrate that even in a study design in which high levels of apoptosis-inducing factors are generated, such as cortisol and isoprostanes, lymphocyte apoptosis does not contribute to post-exercise lymphocytopenia.
Authors:
Adam Steensberg; Jason Morrow; Anders Dyhr Toft; Helle Bruunsgaard; Bente Klarlund Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2002-03-14
Journal Detail:
Title:  European journal of applied physiology     Volume:  87     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2003-01-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Affiliation:
The Copenhagen Muscle Research Centre, and The Department of Infectious Diseases Rigshospitalet, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, 2100 Copenhagen, Denmark. sberg@rh.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / immunology*
Epinephrine / blood
F2-Isoprostanes / immunology*
Humans
Hydrocortisone / blood
Lymphocyte Count
Lymphocytes / cytology*
Lymphopenia / physiopathology
Male
Middle Aged
Norepinephrine / blood
Oxidative Stress / immunology
Physical Endurance / immunology*
Reactive Oxygen Species / metabolism
Grant Support
ID/Acronym/Agency:
CA77839/CA/NCI NIH HHS; DK26657/DK/NIDDK NIH HHS; DK48831/DK/NIDDK NIH HHS; GM15431/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/F2-Isoprostanes; 0/Reactive Oxygen Species; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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