| Prolonged exercise causes an increase in the activity of galactosylhydroxylysyl glucosyltransferase and in the concentration of type III procollagen aminopropeptide in human serum. | |
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MedLine Citation:
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PMID: 2947039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of prolonged heavy physical exercise on serum galactosylhydroxylysyl glucosyltransferase activity (S-GGT) and serum type III procollagen aminoterminal propeptide (S-Pro(III)-N-P) concentration was studied in healthy male long-distance runners. S-GGT increased gradually by about 70% (p less than 0.01) during a competitive 24-h run, and a rising trend was also observed in S-Pro(III)-N-P. After the termination of the run S-GGT was normalized in two days, but the increase in S-Pro(III)-N-P continued up to one day after the race, reaching nearly 40% (p less than 0.005). The alterations in S-GGT and S-Pro(III)-N-P showed no significant correlation with S-CK, S-LDH or the distance run. The most likely explanation for the increases in S-GGT and S-Pro(III)-N-P is that prolonged heavy exercise injures the collagen-synthesizing cells of the connective tissue, leading to a short-term increase in type III procollagen production. |
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Authors:
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T E Takala; J Vuori; H Anttinen; K Väänänen; R Myllylä |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 407 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-01-12 Completed Date: 1987-01-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 500-3 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Proteins / analysis Collagen / biosynthesis Creatine Kinase / blood Glucosyltransferases / blood* Humans L-Lactate Dehydrogenase / blood Male Muscles / metabolism Peptide Fragments / blood* Physical Exertion* Procollagen / blood* Running Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Peptide Fragments; 0/Procollagen; 0/procollagen Type III-N-terminal peptide; 9007-34-5/Collagen; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.4.1.-/Glucosyltransferases; EC 2.4.1.66/UDP glucose-collagen glucosyltransferase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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