Document Detail

Prolonged estrogen-progesterone treatment of nonpregnant ovariectomized rats: factors stimulating home-cage and maternal aggression and short-latency maternal behavior.
MedLine Citation:
PMID:  2227848     Owner:  NLM     Status:  MEDLINE    
A 16-day treatment of nonpregnant, ovariectomized rats using 5-mm Silastic implants of estradiol (E), daily injections of 4 mg of progesterone (P), and terminal injections of 5 micrograms/kg of estradiol benzoate (EB) to provide a pregnancy-like pattern of hormone exposure, stimulates (a) home-cage aggression toward unfamiliar intruder rats, (b) short-latency maternal behavior when the females are exposed continuously to pups, and (c) maternal aggression after maternal care has been initiated. Preliminary experiments examined the persistence of stimulation of aggression by the 16-day treatment in the absence of exposure to pups eliciting maternal care, and whether an abbreviated, 1-week treatment stimulates aggression equally. Subsequent experiments examined the importance of the elements of the treatment (E implants, P injections, EB injection), and whether prolonging exposure to P or E would alter its behavioral effects. The full 16-day E/P/EB treatment stimulated higher levels of home-cage and maternal aggression, and shorter maternal behavior latencies than abbreviated and partial treatments. E in combination with P or EB significantly raised home-cage aggression, whereas P alone was without effect. Administering P for 2 additional days attenuated reductions in maternal behavior latencies by E/P/EB, but did not reduce home-cage or maternal aggressiveness. Continuous exposure to E throughout testing did not affect any dependent variable. Comparing these findings to earlier data and reports suggests that hormone exposure for 2 weeks or more, and provision of P levels approaching those of pregnancy are important to the effects of the E/P/EB treatment on aggression.
A D Mayer; M A Monroy; J S Rosenblatt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormones and behavior     Volume:  24     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-64     Citation Subset:  IM    
Institute of Animal Behavior, Rutgers-State University of New Jersey, Newark 07102.
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MeSH Terms
Aggression / drug effects*
Agonistic Behavior / drug effects
Estradiol / pharmacology*
Maternal Behavior*
Progesterone / pharmacology*
Rats, Inbred Strains
Reaction Time / drug effects
Social Environment*
Grant Support
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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