Document Detail

Prolonged effects of short-term fosinopril on blood pressure and vascular morphology and function in rats.
MedLine Citation:
PMID:  9324110     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the delayed effects of an angiotensin converting enzyme (ACE) inhibitor on blood pressure and on structural and functional alterations in mesenteric small resistance arteries of spontaneously hypertensive rats (SHR). The ACE inhibitor fosinopril (25 mg/kg/day) was administered according to three different schedules: in one group of SHR from 4 to 8 weeks of age (n = 12), in a second group from 8 to 12 weeks of age (n = 15), and in a third group from 4 to 12 weeks of age (n = 12). Eighteen untreated SHR and 18 untreated Wistar-Kyoto rats served as controls. About half the animals in each group were killed at 13 weeks of age, and the remaining were killed at 38 weeks of age. After death, relative left ventricular mass (left ventricular weight/body weight) was calculated. Vascular morphology (media:lumen ratio) and function (responses to norepinephrine and acetylcholine) in mesenteric small resistance arteries were then assessed using a micromyographic technique. Short-term fosinopril, given either before or after the development of hypertension, persistently reduced (but did not normalize) systolic blood pressure, vascular structural alterations, and reactivity to norepinephrine in mesenteric resistance arteries in SHR. These favorable effects were maintained at least for 26 to 30 weeks after treatment withdrawal. The endothelium-dependent vasodilator response to acetylcholine was improved at 13 but not at 38 weeks of age, in treated SHR. Therefore, the vascular response to norepinephrine seems to be dependent mainly on the structure of the vessels, whereas endothelial function is probably more linked to the hemodynamic load.
D Rizzoni; M Castellano; E Porteri; G Bettoni; M L Muiesan; A Cinelli; R Zulli; E A Rosei
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  10     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1034-43     Citation Subset:  IM    
Cattedra di Semeiotica e Metodologia Medica, U.O.P. Scienze Mediche, University of Brescia, Italy.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects
Endothelium, Vascular / drug effects,  physiology
Fosinopril / pharmacology*
Heart / anatomy & histology,  drug effects
Mesenteric Arteries / anatomy & histology,  drug effects*,  physiology
Norepinephrine / pharmacology
Organ Size / drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Time Factors
Vascular Resistance / physiology
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 98048-97-6/Fosinopril

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