Document Detail

Prolonged effect of CGRP in Raynaud's patients: a double-blind randomised comparison with prostacyclin.
MedLine Citation:
PMID:  1931469     Owner:  NLM     Status:  MEDLINE    
1. Calcitonin gene related peptide (CGRP) is a potent endogenous vasodilator to which we have previously demonstrated a specific hypersensitivity in skin blood flow in the hands in patients with Raynaud's disease. 2. We have now investigated whether long infusion of CGRP can relieve symptoms of patients with Raynaud's disease using prostacyclin as a control. 3. Six patients were randomised to receive intravenous infusion of either human alpha-CGRP on one occasion, or prostacyclin (PGI2) on another occasion in a double-blind and cross-over design. The dose of each agent was initially titrated up to 8 ng kg-1 min-1 or to a maximum increase in heart rate of 25 beats min-1. 4. In addition to blood pressure, heart rate and skin blood flow measurements, infrared thermography and cold stress challenge was performed before, immediately after infusion and at 3 and 14 days post-infusion. 5. CGRP caused an increase in hand skin blood flow throughout its infusion, whilst PGI2 caused only a short lived increase. The thermographic results showed significant improvement in hand rewarming 3 days after CGRP but not after PGI2. 6. We conclude that 3 h infusion of CGRP was better tolerated than PGI2 and caused objective improvement up to 3 days. CGRP may be an alternative to PGI2 in some patients.
S Shawket; C Dickerson; B Hazleman; M J Brown
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  32     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-26     Completed Date:  1991-12-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge.
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MeSH Terms
Blood Pressure / drug effects
Body Temperature / drug effects
Calcitonin Gene-Related Peptide / therapeutic use*
Cold Temperature / adverse effects
Double-Blind Method
Epoprostenol / therapeutic use*
Flushing / chemically induced
Heart Rate / drug effects
Middle Aged
Raynaud Disease / drug therapy*,  physiopathology
Regional Blood Flow / drug effects
Skin / blood supply
Stress, Physiological / physiopathology
Reg. No./Substance:
35121-78-9/Epoprostenol; 83652-28-2/Calcitonin Gene-Related Peptide

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