| Prolonged diuretic administration and myocardial tolerance to ischaemia. | |
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MedLine Citation:
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PMID: 3432204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hearts from rats, which received high doses of furosemide alone or the same doses of furosemide plus amiloride in a diet with low magnesium content for 4 weeks, were isolated and perfused in the Langendorff mode. After 15 min. of normoxic control perfusion no differences were found between the two groups of hearts with respect to cardiac physiology. After 20 min. of subtotal, global ischaemia and 15 min. of reperfusion the furosemide plus amiloride hearts showed a significantly higher recovery of function (judged by pressure rate product and coronary flow rate) than furosemide hearts. However, the myocardial content of adenosine triphosphate, creatine phosphate, and electrolytes at the end of the experiment exhibited no difference between the two groups. In separate experiments it was found that the addition of amiloride to the furosemide regimen significantly raised and almost normalized the values of plasma magnesium and potassium. Myocardial calcium was lower, whereas the magnesium and potassium content in the hearts was not different from the furosemide group. It is concluded that the administration of amiloride to rats provided high doses of furosemide and marginal magnesium supplies afforded some protection upon the ischaemic heart. |
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Authors:
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P C Borchgrevink; P Jynge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 61 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-03-04 Completed Date: 1988-03-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 254-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Amiloride / pharmacology Animals Coronary Circulation / drug effects Coronary Disease / physiopathology* Diuretics / pharmacology* Electrolytes / blood, metabolism Furosemide / pharmacology Heart / drug effects*, physiopathology Male Perfusion Phosphocreatine / metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Electrolytes; 2609-46-3/Amiloride; 54-31-9/Furosemide; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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