Document Detail

Prolonged diuretic administration and myocardial tolerance to ischaemia.
MedLine Citation:
PMID:  3432204     Owner:  NLM     Status:  MEDLINE    
Hearts from rats, which received high doses of furosemide alone or the same doses of furosemide plus amiloride in a diet with low magnesium content for 4 weeks, were isolated and perfused in the Langendorff mode. After 15 min. of normoxic control perfusion no differences were found between the two groups of hearts with respect to cardiac physiology. After 20 min. of subtotal, global ischaemia and 15 min. of reperfusion the furosemide plus amiloride hearts showed a significantly higher recovery of function (judged by pressure rate product and coronary flow rate) than furosemide hearts. However, the myocardial content of adenosine triphosphate, creatine phosphate, and electrolytes at the end of the experiment exhibited no difference between the two groups. In separate experiments it was found that the addition of amiloride to the furosemide regimen significantly raised and almost normalized the values of plasma magnesium and potassium. Myocardial calcium was lower, whereas the magnesium and potassium content in the hearts was not different from the furosemide group. It is concluded that the administration of amiloride to rats provided high doses of furosemide and marginal magnesium supplies afforded some protection upon the ischaemic heart.
P C Borchgrevink; P Jynge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  61     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-04     Completed Date:  1988-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Norway.
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MeSH Terms
Adenosine Triphosphate / metabolism
Amiloride / pharmacology
Coronary Circulation / drug effects
Coronary Disease / physiopathology*
Diuretics / pharmacology*
Electrolytes / blood,  metabolism
Furosemide / pharmacology
Heart / drug effects*,  physiopathology
Phosphocreatine / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Diuretics; 0/Electrolytes; 2609-46-3/Amiloride; 54-31-9/Furosemide; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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