| Prolonged bone marrow and skin allograft survival after pretransplant conditioning with cyclophosphamide and total lymphoid irradiation. | |
| | |
MedLine Citation:
|
PMID: 6990564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Current studies were designed to provide long-term survival of allogeneic skin and bone marrow in mice preconditioned with various combinations of cyclophosphamide (CY) and/or total lymphoid irradiation (TLI). Long-term skin graft and bone marrow survival was obtained across the major histocompatibility barrier (BALB/c into C57BL/6) using pregrafting conditioning with either fractionated TLI or the combination of CY with a single dose of TLI. CY alone and a single dose of TLI alone were relatively ineffective as pregrafting immunosuppressive combinations. Allogeneic bone marrow was required for long-term skin graft survival with either conditioning regimen. Allogeneic marrow transplantation resulted in somewhat more deaths than syngeneic transplantation with both CY + TLI and fractionated TLI. |
| | |
Authors:
|
J H Kersey; J Kruger; C Song; B Kloster |
Related Documents
:
|
9167634 - Effect of freeze-drying or gamma-irradiation on remodeling of tendon allograft in a rat... 1437034 - Effects of total body irradiation on salivary gland function and caries-associated oral... 12109694 - Thermomechanical behavior of virgin and highly crosslinked ultra-high molecular weight ... 6437834 - Whole-body elemental composition in patients with renal failure and after transplantati... 11850704 - The use of zanamivir to treat influenza a and b infection after allogeneic stem cell tr... 19460514 - Surveillance of human papilloma virus infection and cervical cancer in kidney transplan... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Transplantation Volume: 29 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1980 May |
Date Detail:
|
Created Date: 1980-07-28 Completed Date: 1980-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 388-91 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bone Marrow Transplantation* Chimera / radiation effects Cyclophosphamide / pharmacology* Graft Survival / drug effects, radiation effects Lymphoid Tissue / immunology, radiation effects* Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Radiation Dosage Skin Transplantation* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
|
50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of T cell function with a skin allograft assay.
Next Document: Massive post-transplant proteinuria with minimal histological changes.