Document Detail

Prolonged atrial fibrillation following generalized tonic-clonic seizures.
MedLine Citation:
PMID:  22698381     Owner:  NLM     Status:  MEDLINE    
We describe two male patients with focal epilepsy in whom transitory episodes of atrial fibrillation (AF) lasting for up to 25h were detected in the context of generalized tonic-clonic seizures (GTCSs). In five of seven previously published cases of transitory AF associated with epileptic seizures, AF was also associated with GTCS, suggesting a pathophysiological link via GTCS-related increase in sympathetic tone and release of catecholamines. Importantly, AF increases the risk of thromboembolic cerebral ischemia, prompting the question of whether antithrombotic preventive treatment should be initiated in people with pharmacoresistant epilepsy and prolonged peri-ictal AF. Furthermore, AF can considerably impair cardiac output and may, via this mechanism, contribute to the risk of sudden unexpected death in epilepsy following GTCS.
Rainer Surges; Susanna Moskau; Bettina Viebahn; Jan-Christoph Schoene-Bake; Joerg O Schwab; Christian E Elger
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-12
Journal Detail:
Title:  Seizure : the journal of the British Epilepsy Association     Volume:  21     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-21     Completed Date:  2013-01-03     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  643-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Atrial Fibrillation / etiology*,  physiopathology
Seizures / complications*,  physiopathology
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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