Document Detail


Prolonged analgesia by enkephalinase inhibition in rats with spinal cord adrenal medullary transplants.
MedLine Citation:
PMID:  2364994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transplants of adrenal medullary tissue or isolated chromaffin cells into the spinal cord subarachnoid space has been shown to reduce pain sensitivity in rats. This analgesia probably results from the release of neuroactive substances, particularly opioid peptides, from the transplanted cells since it is induced by nicotinic stimulation of chromaffin cell receptors, and can be blocked by naloxone. However, this analgesia is short-lived, most likely due to the rapid hydrolysis of opioid peptides. The purpose of this study was to determine whether protection of opioid peptide hydrolysis by the potent enkephalinase inhibitor kelatorphan could prolong this analgesia. Results indicated that the intrathecal injection of kelatorphan in animals with either adrenal medullary or chromaffin cell implants significantly prolonged nicotine-stimulated analgesia. Pretreatment with naloxone completely eliminated this analgesia. These results suggest that it may be possible to induce long-term reductions in pain sensitivity using enkephalinase inhibitors following the transplantation of opioid peptide-producing cells into the CNS.
Authors:
J Sagen; H Wang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  179     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  427-33     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, University of Illinois, Chicago 60612.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / transplantation*
Analgesia*
Animals
Chromaffin System / cytology,  physiology
Dipeptides / pharmacology
Male
Naloxone / pharmacology
Neprilysin / antagonists & inhibitors*
Pain Measurement
Rats
Rats, Inbred Strains
Spinal Cord / physiology*
Transplantation, Heterotopic*
Grant Support
ID/Acronym/Agency:
NS25054/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Dipeptides; 465-65-6/Naloxone; 92175-57-0/kelatorphan; EC 3.4.24.11/Neprilysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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