Document Detail


Prolonged administration of isoflurane to pediatric patients during mechanical ventilation.
MedLine Citation:
PMID:  8452259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We undertook a prospective study of the effectiveness and potential toxicities of isoflurane sedation in pediatric patients undergoing mechanical ventilation who required large doses of opioids for sedation were considered eligible. Ten patients (ages 3 wk to 19 yr) received continuous isoflurane sedation for a mean duration of 131 minimum alveolar concentration (MAC)-hours (range 13-497 MAC-hours). The mean peak inorganic fluoride (F-) concentration was 11.0 microM, and the highest F- concentration was 26.1 microM after 441 MAC-hours. Only one patient had a measured F- concentration greater than 20 microM. No abnormalities were noted in serum creatinine or osmolality. Creatinine clearances were available for five patients who received a mean of 193 MAC-hours of isoflurane (range 33-497 MAC-hours), and only one patient had a persistent decrease from baseline of more than 20%. Five patients demonstrated an abstinence syndrome which consisted of nonpurposeful movements and extreme agitation. All of these patients had received at least 70 MAC-hours of isoflurane. Our experience indicates that isoflurane can effectively provide sedation to pediatric patients for prolonged periods without significant adverse effects on cardiovascular, hepatic, or renal function.
Authors:
J H Arnold; R D Truog; S A Rice
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  76     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-09     Completed Date:  1993-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, Children's Hospital, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Child, Preschool
Female
Humans
Hypnotics and Sedatives / administration & dosage*,  adverse effects
Infant
Infant, Newborn
Isoflurane / administration & dosage*,  adverse effects
Male
Prospective Studies
Respiration, Artificial*
Time Factors
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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