| Prolonged action potential duration of guinea-pig heart muscle after pethidine. | |
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MedLine Citation:
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PMID: 2333277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since recent experiments indicated class III antiarrhythmic properties of pethidine in vitro, we studied cardiac effects of pethidine in vivo. Monophasic action potentials at different pacing rates were recorded from the left ventricular epicardium of pentobarbital anaesthetized guinea-pigs by means of suction electrode catheter. Intravenous injection of pethidine 2 mg/kg prolonged the action potential duration, and increased left ventricular developed pressure and dP/dt max, compared to animals receiving saline only. It is concluded that pethidine appears to have class III antiarrhythmic properties. |
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Authors:
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K G Helgesen; H Refsum |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 66 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-06-06 Completed Date: 1990-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: IM |
Affiliation:
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Institute of Medical Biology, University of Tromsø, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Female Guinea Pigs Heart / drug effects, physiology* Heart Rate / drug effects Injections, Intravenous Meperidine / pharmacology* Myocardial Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
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57-42-1/Meperidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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