Document Detail

Prolonged Survival in an Aged Labrador Retriever with a Metastatic Insulinoma.
MedLine Citation:
PMID:  23325593     Owner:  NLM     Status:  Publisher    
This case report highlights an unusually prolonged, asymptomatic, disease-free interval in an aged male Labrador retriever that underwent partial pancreatectomy for a functionally active pancreatic insulinoma with histologically confirmed hepatic metastasis. The patient developed pancreatitis and nonseptic suppurative peritonitis 24 hr after surgical resection of the insulinoma and was managed medically until discharge. Three mo after surgery, the dog was diagnosed with exocrine pancreatic insufficiency (EPI) that was effectively managed with parenteral pancreatic enzymes. Due to normal glucose levels 3 mo postsurgically, liver samples from the initial surgery were resubmitted for immunohistochemistry. Results confirmed insulinoma metastasis with insulin expression. Ten mo postsurgically, the blood glucose was normal and serum insulin levels were slightly above the upper reference limit. The first hypoglycemic episode was documented 23 mo postoperatively, which was effectively managed with prednisone. The cause for the prolonged disease remission and survival was unknown, but was possibly a result of pancreatitis and peritonitis, partial spontaneous regression of metastatic lesions, or idiopathic. Despite life-threatening postoperative complications, this patient enjoyed a profoundly longer than expected survival. This case highlights the importance of removing the primary tumor (insulinoma) despite the presence of metastatic disease.
Jessica Rychel; Deanna R Worley; Christine S Hardy; Brett T Webb
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  -     ISSN:  1547-3317     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fort Collins Veterinary Emergency and Rehabilitation Hospital, Fort Collins, CO, Colorado State University, Fort Collins, CO.
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