Document Detail

Prolonged Sinus Pauses with Hydromorphone in the Absence of Cardiac Conduction Disease.
MedLine Citation:
PMID:  21297541     Owner:  NLM     Status:  Publisher    
A 49-year-old male had open sigmoid colectomy with colorectal anastomosis for sigmoid diverticulitis. The patient was given patient-controlled analgesia (PCA) hydromorphone and subsequently developed bradycardia with prolonged sinus pauses up to 7.1 seconds. The pauses resolved shortly after the hydromorphone was discontinued. This is the first case report to our knowledge of reversible prolonged sinus pauses associated with the use of hydromorphone. Animal studies support a role for opioid signaling at the sinoatrial (SA) node. Hydromorphone is a potential cause of prolonged sinus pauses and should be taken into consideration when monitoring a patient on hydromorphone for pain control.
Brian S Snarr; Christopher P Rowley; Stephanie V Phan; Anand Achanti; Grady H Hendrix
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-3
Journal Detail:
Title:  Southern medical journal     Volume:  -     ISSN:  1541-8243     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC.
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