Document Detail


Prolonged Q-T interval and severe tachyarrhythmias, common features of sotalol intoxication.
MedLine Citation:
PMID:  7262178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The findings in six patients admitted to hospital 0.5-4.5 h after the ingestion of an overdose of 2.4-8 g sotalol are described. In addition to bradycardia and hypotension, all patients had a considerably prolonged corrected Q-T interval, up to 172 +/- 8% of normal. Severe ventricular tachyarrhythmias occurred in five of the six patients, the risk was greatest up to 20 h after the ingestion of sotalol. The long Q-T interval returned to normal over 3 to 4 days, which is consistent with the long half-life of sotalol. In addition to its beta-blocking action, sotalol has marked electrophysiological properties of a Class III antiarrhythmic drugs, which are likely to be able to account for its observed effects. Special attention should be paid to the risk of severe ventricular arrhythmias in sotalol intoxications.
Authors:
P J Neuvonen; E Elonen; T Vuorenmaa; M Laakso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  20     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-29     Completed Date:  1981-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arrhythmias, Cardiac / chemically induced*,  physiopathology
Electrocardiography
Female
Hemodynamics / drug effects
Humans
Male
Middle Aged
Sotalol / poisoning*
Tachycardia / chemically induced,  physiopathology
Chemical
Reg. No./Substance:
3930-20-9/Sotalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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