| Prolonged Intravenous Infusion of Sodium Nitrite Delivers Nitric Oxide (NO) in Humans. | |
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MedLine Citation:
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PMID: 22890643 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In preclinical studies, infusion of sodium nitrite delivers nitric oxide (NO) as treatment of vasospasm after subarachnoid hemorrhage. We evaluated safety and toxicity of intravenous nitrite administration in healthy volunteers infused with increasing doses of sodium nitrite for 48 h. Twelve volunteers (5 men, 7 women; mean age was 38.8 years, range 27-56 years) participated in the study. The starting sodium nitrite dose was 4.2 mg/kg/h, and it was doubled for each subsequent volunteer up to a maximal dose of 533.8 mg/kg/h at which a clinically silent dose-limiting toxicity (DLT) was observed. Toxicity included a transient decrease of mean arterial blood pressure or asymptomatic increase of methemoglobin level above 5%. The maximal tolerated dose (MTD) was 267 mg/kg/h. S-Nitrosothiols increased significantly in plasma, confirming in vivo sodium nitrite reduction to NO and encouraging its use against vasospasm and ischemia-reperfusion injury to the brain, kidneys, liver, and heart. |
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Authors:
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Ryszard M Pluta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplement Volume: 115 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-08-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
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Languages: eng Pagination: 49-51 Citation Subset: IM |
Affiliation:
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Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 5512 Pembroke Terrace, Bethesda, MD, USA, rysiek@ninds.nih.gov. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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