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Prolonged GnRH suppression period in controlled ovarian hyperstimulation cycles: Impacts on IVF outcomes?
MedLine Citation:
PMID:  25242990     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prolonged GnRH-a administration in IVF cycles may have some advantages related to the treatment outcomes.
OBJECTIVE: In this study, we aimed to analyse the effect of prolonged gonadotropin releasing hormone agonist (GnRH-a) administration on controlled ovarian hyperstimulation outcomes of in vitro fertilization (IVF) patients.
MATERIALS AND METHODS: In this retrospective study, 55 patients with a GnRH-a administration period more than 10 days were compared with 55 patients whose same period was ≤10 days with respect to the demographic characteristics, metaphase II (MII) oocyte ratio, grade I (GI) embryo ratio, blastocyst ratio, fertilization, implantation, and the clinical pregnancy rates.
RESULTS: The mean hospital visit count of the prolonged GnRH-a patients was 2.6±0.4. As we expected, total GnRH-a doses used during hypophyseal down regulation were significantly different between the groups (p<0.0001). MII oocyte, G1 embryo and the blastocyst ratios were also significantly different between the groups (p<0.0001; p<0.01 and p<0.05). All the other parameters were insignificant.
CONCLUSION: Prolonged GnRH-a administration during ovarian suppression in IVF patients may have positive impacts on the oocytes and the embryos, but this affect may not be observed in the overall pregnancy rates.
Authors:
Ozlem Gun Eryilmaz; Esma Sarikaya; Melike Doganay; Leyla Mollamahmutoglu; Nedim Cicek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of reproductive medicine     Volume:  10     ISSN:  1680-6433     ISO Abbreviation:  Iran J Reprod Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2014-09-22     Completed Date:  2014-09-22     Revised Date:  2014-10-03    
Medline Journal Info:
Nlm Unique ID:  101463749     Medline TA:  Iran J Reprod Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  -    
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