Document Detail

Prolonged GnRH suppression period in controlled ovarian hyperstimulation cycles: Impacts on IVF outcomes?
MedLine Citation:
PMID:  25242990     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Prolonged GnRH-a administration in IVF cycles may have some advantages related to the treatment outcomes.
OBJECTIVE: In this study, we aimed to analyse the effect of prolonged gonadotropin releasing hormone agonist (GnRH-a) administration on controlled ovarian hyperstimulation outcomes of in vitro fertilization (IVF) patients.
MATERIALS AND METHODS: In this retrospective study, 55 patients with a GnRH-a administration period more than 10 days were compared with 55 patients whose same period was ≤10 days with respect to the demographic characteristics, metaphase II (MII) oocyte ratio, grade I (GI) embryo ratio, blastocyst ratio, fertilization, implantation, and the clinical pregnancy rates.
RESULTS: The mean hospital visit count of the prolonged GnRH-a patients was 2.6±0.4. As we expected, total GnRH-a doses used during hypophyseal down regulation were significantly different between the groups (p<0.0001). MII oocyte, G1 embryo and the blastocyst ratios were also significantly different between the groups (p<0.0001; p<0.01 and p<0.05). All the other parameters were insignificant.
CONCLUSION: Prolonged GnRH-a administration during ovarian suppression in IVF patients may have positive impacts on the oocytes and the embryos, but this affect may not be observed in the overall pregnancy rates.
Ozlem Gun Eryilmaz; Esma Sarikaya; Melike Doganay; Leyla Mollamahmutoglu; Nedim Cicek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of reproductive medicine     Volume:  10     ISSN:  1680-6433     ISO Abbreviation:  Iran J Reprod Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2014-09-22     Completed Date:  2014-09-22     Revised Date:  2014-10-03    
Medline Journal Info:
Nlm Unique ID:  101463749     Medline TA:  Iran J Reprod Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  -    
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