Document Detail

Prolonged and exclusive breastfeeding reduces the risk of infectious diseases in infancy.
MedLine Citation:
PMID:  20566605     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy. METHODS: This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life onward in the Netherlands. Rates of breastfeeding during the first 6 months (never; partial for <4 months, not thereafter; partial for 4-6 months; exclusive for 4 months, not thereafter; exclusive for 4 months, partial thereafter; and exclusive for 6 months) and doctor-attended infections in the URTI, LRTI, and GI until the age of 12 months were assessed by questionnaires and available for 4164 subjects. RESULTS: Compared with never-breastfed infants, those who were breastfed exclusively until the age of 4 months and partially thereafter had lower risks of infections in the URTI, LRTI, and GI until the age of 6 months (adjusted odds ratio [aOR]: 0.65 [95% confidence interval (CI): 0.51-0.83]; aOR: 0.50 [CI: 0.32-0.79]; and aOR: 0.41 [CI: 0.26-0.64], respectively) and of LRTI infections between the ages of 7 and 12 months (aOR: 0.46 [CI: 0.31-0.69]). Similar tendencies were observed for infants who were exclusively breastfed for 6 months or longer. Partial breastfeeding, even for 6 months, did not result in significantly lower risks of these infections. CONCLUSIONS: Exclusive breastfeeding until the age of 4 months and partially thereafter was associated with a significant reduction of respiratory and gastrointestinal morbidity in infants. Our findings support health-policy strategies to promote exclusive breastfeeding for at least 4 months, but preferably 6 months, in industrialized countries.
Liesbeth Duijts; Vincent W V Jaddoe; Albert Hofman; Henriëtte A Moll
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-21
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e18-25     Citation Subset:  AIM; IM    
Generation R Study Group, Rotterdam, Netherlands.
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MeSH Terms
Age Factors
Breast Feeding / statistics & numerical data*
Cohort Studies
Communicable Disease Control / methods*
Communicable Diseases / epidemiology
Confidence Intervals
Diarrhea, Infantile / epidemiology,  immunology,  prevention & control*
Follow-Up Studies
Gastroenteritis / epidemiology,  immunology,  prevention & control
Infant, Newborn
Odds Ratio
Primary Prevention / methods
Prospective Studies
Reference Values
Respiratory Tract Infections / epidemiology,  immunology,  prevention & control*
Risk Assessment
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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