Document Detail


Prolongation of the tibialis anterior CMAP duration in chronic inflammatory demyelinating polyneuropathy.
MedLine Citation:
PMID:  21767985     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To assess the duration of the distal compound muscle action potential (dCMAP) recording from the tibialis anterior (TA) as a supportive electrodiagnostic feature in chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: We performed peroneal motor conduction studies with recording from the TA in 35 CIDP patients, 30 normal controls, and 21 disease controls. The normal cut-off for the TA dCMAP duration was determined to be 14ms. RESULTS: Prolonged TA dCMAP durations were detected in 34% of CIDP patients (12/35) and in 33% (2/6) of patients in whom only one demyelinating lesion was identified by conventional motor conduction studies. Prolonged TA dCMAP durations were present in 28% (5/18) of patients with normal duration dCMAPs recorded from the abductor hallucis (AH) and in 42% (5/12) of patients with normal duration dCMAPs recorded from the extensor digitorum brevis (EDB). In patients with AH or EDB dCMAP amplitudes <1mV, TA dCMAP durations were prolonged in 28% and 23% of patients, respectively. CONCLUSIONS: Determination of TA dCMAP duration appears to be useful for detecting demyelination in CIDP, especially when there is significant coexisting axon loss. SIGNIFICANCE: In patients with potential CIDP and limited electrodiagnostic abnormalities by routine studies, the finding of additional demyelinating findings, such as increased TA dCMAP duration, could allow for improved diagnostic sensitivity.
Authors:
Hiroyuki Nodera; Norman Latov; Bridget Carey; Jennifer Langsdorf; Veronica Bedoya; Svetla Tacheva; Russell L Chin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-16
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Peripheral Neuropathy Center, Department of Neurology, Weill Cornell Medical College, New York, NY, USA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
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