Document Detail

Prolongation of the tibialis anterior CMAP duration in chronic inflammatory demyelinating polyneuropathy.
MedLine Citation:
PMID:  21767985     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess the duration of the distal compound muscle action potential (dCMAP) recording from the tibialis anterior (TA) as a supportive electrodiagnostic feature in chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: We performed peroneal motor conduction studies with recording from the TA in 35 CIDP patients, 30 normal controls, and 21 disease controls. The normal cut-off for the TA dCMAP duration was determined to be 14ms. RESULTS: Prolonged TA dCMAP durations were detected in 34% of CIDP patients (12/35) and in 33% (2/6) of patients in whom only one demyelinating lesion was identified by conventional motor conduction studies. Prolonged TA dCMAP durations were present in 28% (5/18) of patients with normal duration dCMAPs recorded from the abductor hallucis (AH) and in 42% (5/12) of patients with normal duration dCMAPs recorded from the extensor digitorum brevis (EDB). In patients with AH or EDB dCMAP amplitudes <1mV, TA dCMAP durations were prolonged in 28% and 23% of patients, respectively. CONCLUSIONS: Determination of TA dCMAP duration appears to be useful for detecting demyelination in CIDP, especially when there is significant coexisting axon loss. SIGNIFICANCE: In patients with potential CIDP and limited electrodiagnostic abnormalities by routine studies, the finding of additional demyelinating findings, such as increased TA dCMAP duration, could allow for improved diagnostic sensitivity.
Hiroyuki Nodera; Norman Latov; Bridget Carey; Jennifer Langsdorf; Veronica Bedoya; Svetla Tacheva; Russell L Chin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-16
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Peripheral Neuropathy Center, Department of Neurology, Weill Cornell Medical College, New York, NY, USA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
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