Document Detail

Prolongation of rat major histocompatibility complex-compatible cardiac allograft survival during pregnancy.
MedLine Citation:
PMID:  19201344     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been suggested that pregnancy-related hormones play a critical role in mediating selective immune tolerance during pregnancy. An understanding of why a woman's body normally does not reject the fetus is highly relevant to the prevention of transplant rejection. METHODS: The hearts of female inbred F344 rats (RT-1(lvl)) were transplanted into naive Lewis (RT-1(l); nLewis) or pregnant (pLewis; Day 6, 12 and 18 of pregnancy) rats. The mean survival time (MST) of the cardiac allografts between the nLewis and pLewis rats was compared. We determined the rate of proliferation of the T cells isolated from nLewis and pLewis rats in response to concanavalin A (ConA), anti-CD3 and -CD28 antibody and alloantigen stimulation ex vivo. mRNA expression of several cytokines in these T cells was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the effect of estriol on the cardiac allograft was tested. RESULTS: The pLewis rats with transplant on Day 12 of pregnancy had the most significantly prolonged F344 cardiac graft survival (MST 13.3 days) as compared with nLewis recipients (MST 8 days). pLewis T-cell proliferation was stimulated by alloantigen and antibody but ConA was reduced, whereas Th1/Th2 cytokine mRNA profiles in the T cells were similar for nLewis and pLewis rats. Likewise, estriol also significantly prolonged survival of cardiac allografts. CONCLUSIONS: The results of this study demonstrate that pregnancy hormones not only appear to play a critical role in maternal acceptance of the fetus, but also have therapeutic potential for prolonging the survival of major histocompatibility complex (MHC)-compatible allografts during pregnancy.
Naoko Funeshima-Fuji; Masayuki Fujino; Lin Xie; Hiromitsu Kimura; Shiro Takahara; Taichi Ezaki; Bao Ting Zhu; Xiao-Kang Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  28     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-82     Citation Subset:  IM    
Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
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MeSH Terms
Concanavalin A / pharmacology
Cytokines / genetics
Estriol / therapeutic use
Graft Survival / drug effects
Heart Transplantation / immunology*,  pathology
Lymphocyte Activation / drug effects
Major Histocompatibility Complex*
Pregnancy, Animal / immunology*
RNA, Messenger / genetics,  isolation & purification
Rats, Inbred F344
Rats, Inbred Lew
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
T-Lymphocytes / drug effects,  immunology
Transplantation, Heterotopic / immunology,  pathology
Transplantation, Homologous / pathology
Reg. No./Substance:
0/Cytokines; 0/RNA, Messenger; 11028-71-0/Concanavalin A; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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