| Prolongation and optimization of Doppler enhancement with a microbubble US contrast agent by using continuous infusion: preliminary experience. | |
| | |
MedLine Citation:
|
PMID: 9577478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To investigate whether continuous infusion of an echo-enhancing contrast agent for up to 15 minutes can provide uniform and prolonged enhancement. MATERIALS AND METHODS: Six volunteers each received one bolus and three infusions of a microbubble contrast agent over 6-15 minutes at (a) a standard rate (mean, 2.08 mL/min), (b) a fast rate at twice the standard rate, and (c) a slow rate at half the standard rate. Spectral Doppler intensitometry of the femoral artery was performed for all infusions. Spectral Doppler ultrasound (US) scans of the femoral artery and color Doppler US scans of the carotid artery were subjectively assessed. RESULTS: All infusions provided an equilibrium plateau of constant prolonged enhancement starting after 1-2 minutes and lasting until the end of the infusion. Enhancement at the plateau was +13 dB (slow rate), +17.1 dB (standard rate), and +18.3 dB (fast rate) compared with baseline. Saturation artifacts with infusions were markedly fewer than those with bolus injections. Dose effectiveness (duration of enhancement that measured at least 7.5 dB per gram of contrast agent) was markedly improved with the infusions, from 0.8 min/g for the bolus to 2.6 min/g for the slow infusion. CONCLUSION: Continuous infusion of the microbubble contrast agent provided prolonged and uniform enhancement of Doppler signals and improved image quality by minimizing saturation artifacts. |
| | |
Authors:
|
T Albrecht; A Urbank; M Mahler; A Bauer; C J Doré; M J Blomley; D O Cosgrove; R Schlief |
Related Documents
:
|
11800038 - Spontaneous and repetitive cardiac slowdown in the freely moving spiny lobster, panulir... 18595438 - Increased heart rate variability but normal resting metabolic rate in hypocretin/orexin... 23153688 - Hypertension caused by primary hyperaldosteronism: increased heart damage and cardiovas... 4326848 - Effects of cold, eating, efferent nerve stimulation and angiotensin on heart rate in sh... 23005538 - Upscaling energy concentration in multifrequency single-bubble sonoluminescence with st... 17556718 - Effects of continuous positive airway pressure on early signs of atherosclerosis in obs... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Radiology Volume: 207 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1998 May |
Date Detail:
|
Created Date: 1998-05-28 Completed Date: 1998-05-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 339-47 Citation Subset: AIM; IM |
Affiliation:
|
Department of Imaging, Hammersmith Hospital, Imperial College, School of Medicine, London, England. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Artifacts Carotid Arteries / ultrasonography* Catheterization, Peripheral Contrast Media / administration & dosage* Dose-Response Relationship, Drug Femoral Artery / ultrasonography* Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods Infusion Pumps Infusions, Intravenous Injections, Intravenous Male Monitoring, Physiologic Observer Variation Polysaccharides / administration & dosage, diagnostic use* Time Factors Ultrasonography, Doppler / methods* Ultrasonography, Doppler, Color Ultrasonography, Doppler, Duplex Ultrasonography, Doppler, Pulsed Videotape Recording |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MR imaging of the liver: comparison between single-shot echo-planar and half-Fourier rapid acquisiti...
Next Document: Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compressio...