| Prolongation of the QT interval in primary aldosteronism. | |
| | |
MedLine Citation:
|
PMID: 15730437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Only limited information is available concerning the changes in the electrocardiogram in primary aldosteronism. The aim of the present study was to determine factors influencing the QTc interval in patients with primary aldosteronism. 2. Nineteen patients with primary aldosteronism caused by a Conn's adenoma and 69 patients with essential hypertension, in whom all possible causes of secondary hypertension had been excluded, were included in the present study. Before and 10-20 days after adrenalectomy, blood and electrocardiographic examinations were conducted. 3. Systolic and diastolic blood pressures in primary aldosteronism were found to be comparable to those in essential hypertension. However, the QTc interval was significantly prolonged and serum potassium concentrations were significantly decreased in patients with primary aldosteronism compared with patients with essential hypertension (492.7+/-20.3 vs 428.5+/-3.1 msec for QTc interval, respectively (P<0.01); 3.07+/-0.12 vs 4.07+/-0.05 mEq/L for serum potassium concentrations, respectively (P<0.01)). The QTc interval was significantly correlated with serum potassium concentrations in primary aldosteronism (P=0.0011; r=-0.6902), but not in patients with essential hypertension. 4. Blood pressure significantly decreased after adrenalectomy. Furthermore, serum potassium concentrations increased significantly and did not correlate with the QTc interval after adrenalectomy (P=0.54; r=-0.1500). 5. Our results indicate that the QTc interval is prolonged in patients with primary aldosteronism, probably owing to hypokalaemia. |
| | |
Authors:
|
Kiyoshi Matsumura; Koji Fujii; Yasuo Kansui; Hisatomi Arima; Mitsuo Iida |
Related Documents
:
|
16330897 - Role of angiotensin ii in the evolution of diastolic heart failure. 8733007 - Mineralocorticoids, salt, hypertension: effects on the heart. 11560127 - Early rise in blood pressure following administration of adrenocorticotropic hormone-[1... 19895757 - Aldosterone and cardiovascular risk. 16399857 - Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of pkc/erk p... 2888317 - Avp-induced pulmonary vasodilation during specific v1 receptor block in conscious dogs. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 32 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2005 Jan-Feb |
Date Detail:
|
Created Date: 2005-02-25 Completed Date: 2005-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
|
Languages: eng Pagination: 66-9 Citation Subset: IM |
Affiliation:
|
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. matsumk@intmed2.med.kyushu-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenalectomy Blood Pressure / physiology Electrocardiography Female Humans Hyperaldosteronism / complications*, physiopathology, surgery Hypertension / physiopathology Long QT Syndrome / etiology*, physiopathology Male Middle Aged Potassium / blood |
| Chemical | |
Reg. No./Substance:
|
7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Block of NA+ and K+ currents in rat ventricular myocytes by quinacainol and quinidine.
Next Document: Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes.