Document Detail

Prolongation of the QT-interval during induction of anesthesia in patients with coronary artery disease.
MedLine Citation:
PMID:  8171949     Owner:  NLM     Status:  MEDLINE    
During induction of anesthesia in 60 patients undergoing coronary artery bypass grafting (CABG), we measured the QT-interval (QTI) in the ECG, heart rate (HR) and mean arterial pressure (MAP). Based on the HR, we corrected the QT-interval (QTcI). Prior to induction, six patients (10%) already had abnormal prolongation of QTcI (> or = 440 ms). After injection of fentanyl and vecuronium, the QTcI increased significantly (P < 0.01); to a far lesser extent after injection of hypnotics (i.e. etomidate, midazolam or propofol). Orotracheal intubation caused significant shortening of QTcI (P < 0.01). HR decreased markedly after injection of fentanyl. MAP decreased, however, only after injection of hypnotics. In the immediate post intubation period, HR and MAP increased significantly. The various hypnotics produced no significant difference in HR and QTcI at any measurement point. MAP changed only after injection of hypnotics. The decrease of HR and MAP during induction of anesthesia is thought to result from a corresponding reduction of adrenosympathetic stimulation. We believe that QTcI is similarly influenced.
V Lischke; H J Wilke; S Probst; M Behne; P Kessler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  38     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Department of Anesthesiology and Resuscitation, J.W. Goethe-University Hospital, Frankfurt/Main, Germany.
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MeSH Terms
Anesthesia, Intravenous*
Blood Pressure / drug effects
Coronary Disease* / physiopathology
Electrocardiography / drug effects*
Etomidate / pharmacology*
Fentanyl / pharmacology
Heart Rate / drug effects
Intubation, Intratracheal
Midazolam / pharmacology*
Middle Aged
Propofol / pharmacology*
Time Factors
Ventricular Function / drug effects
Reg. No./Substance:
2078-54-8/Propofol; 33125-97-2/Etomidate; 437-38-7/Fentanyl; 59467-70-8/Midazolam

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