Document Detail

Prolongation of the QT interval by enflurane, isoflurane, and halothane in humans.
MedLine Citation:
PMID:  1898684     Owner:  NLM     Status:  MEDLINE    
Previous investigations in laboratory animals have documented the ability of the volatile anesthetics to prolong the QT interval and the QT interval corrected for level of heart rate, QTc. The purpose of the present investigation was to evaluate the direct electrocardiographic and hemodynamic effects of enflurane, isoflurane, and halothane in healthy, unpremedicated patients using an inhalation induction to avoid the confounding effects of other anesthetic agents. Experiments were conducted in 22 adult male patients, (ASA physical status I or II) divided into three groups given either enflurane (n = 6), isoflurane (n = 8), or halothane (n = 8) anesthesia. Twenty-four-hour preoperative, preinduction, and postinduction hemodynamic and electrocardiographic measurements were obtained. Anesthetic blood concentrations, levels of plasma electrolytes, and arterial blood gas tensions were also quantitated. Halothane administration (0.81 +/- 0.06 mM) did not significantly alter the PR interval or QRS duration but significantly increased the QT (0.38 +/- 0.01 to 0.45 +/- 0.01 s) and QTc intervals (0.39 +/- 0.01 to 0.44 +/- 0.02 s). Isoflurane anesthesia (1.04 +/- 0.11 mM) did not significantly change QRS duration or PR and QT intervals but significantly prolonged the QTc interval (0.42 +/- 0.01 to 0.47 +/- 0.14 s). Similarly, enflurane anesthesia (2.16 +/- 0.13 mM) significantly prolonged the QTc (0.40 +/- 0.01 to 0.46 +/- 0.14 s) without change in QRS duration or PR and QT intervals. Plasma electrolyte levels and arterial gas tensions remained within normal limits in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)
W T Schmeling; D C Warltier; D J McDonald; K E Madsen; J L Atlee; J P Kampine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  72     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-02-07     Completed Date:  1991-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  AIM; IM    
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Anesthesia, Inhalation* / adverse effects
Carbon Dioxide / blood
Electrocardiography / drug effects*
Electrolytes / blood
Enflurane / pharmacology*
Halothane / pharmacology*
Hemodynamics / drug effects*
Isoflurane / pharmacology*
Middle Aged
Oxygen / blood
Grant Support
Reg. No./Substance:
0/Electrolytes; 124-38-9/Carbon Dioxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane; 7782-44-7/Oxygen

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