| Proliferon: the functional unit of rapidly proliferating organs. | |
| | |
MedLine Citation:
|
PMID: 459968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Continuously replicating organs are generally composed of several cell population types. These may be divided according to their function into two classes: 1. parenchyma: cells destined to perform a certain metabolic function peculiar to the organ under study, 2. supporting cell populations, consisting of fibroblasts and vascular supply always accompanied by nerve fibers. The kinetics of all the cells are highly coordinated. They all share one progenitor region. It is postulated that in this common progenitor region the two cell population classes are assembled into complex units denominated as proliferons. The proliferon starts its existence as a whole, matures as a whole and disintegrates at the organ periphery. It consists of four basic elements: parenchyma, connective tissue, blood vessels and nerve fibers. This model has been previously called upon to describe the kinetics of the rodent incisor tooth and the intestinal mucosa. It is assumed to be the elementary functional unit of all rapidly proliferating organs such as: skin, hair, endometrium, bone marrow, intestinal mucosa and rodent incisor. |
| | |
Authors:
|
G Zajicek |
Related Documents
:
|
1699468 - Immuno-electron microscopic study of keratin distribution in the cochlea using monoclon... 8260618 - Expression of alpha-actinin in the stereocilia of hair cells of the inner ear: immunohi... 3478958 - Hair cell distributions in the normal human cochlea. a report of a european working group. 15806708 - Efficacy of an ototoxic aminoglycoside (gentamicin) on the differentiation of the inner... 15701808 - Radiological studies reveal radial differences in the architecture of the polysaccharid... 1145898 - On the availability of certain metabolites at the outer surface of normal and malignant... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Medical hypotheses Volume: 5 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1979 Jan |
Date Detail:
|
Created Date: 1979-09-17 Completed Date: 1979-09-17 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 161-74 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Bone Marrow / physiology Cell Division* Colonic Neoplasms / etiology Embryonic Induction Endometrium / physiology Female Hair / physiology Humans Hydrazines / adverse effects Kinetics Mice Nerve Fibers / physiology* Rats Skin Neoplasms / etiology Skin Physiological Phenomena |
| Chemical | |
Reg. No./Substance:
|
0/Hydrazines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solar cycles and malignant melanoma.
Next Document: Selectivity and rejectivity in cancer metastasis.