Document Detail


Proliferon: the functional unit of rapidly proliferating organs.
MedLine Citation:
PMID:  459968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuously replicating organs are generally composed of several cell population types. These may be divided according to their function into two classes: 1. parenchyma: cells destined to perform a certain metabolic function peculiar to the organ under study, 2. supporting cell populations, consisting of fibroblasts and vascular supply always accompanied by nerve fibers. The kinetics of all the cells are highly coordinated. They all share one progenitor region. It is postulated that in this common progenitor region the two cell population classes are assembled into complex units denominated as proliferons. The proliferon starts its existence as a whole, matures as a whole and disintegrates at the organ periphery. It consists of four basic elements: parenchyma, connective tissue, blood vessels and nerve fibers. This model has been previously called upon to describe the kinetics of the rodent incisor tooth and the intestinal mucosa. It is assumed to be the elementary functional unit of all rapidly proliferating organs such as: skin, hair, endometrium, bone marrow, intestinal mucosa and rodent incisor.
Authors:
G Zajicek
Related Documents :
1699468 - Immuno-electron microscopic study of keratin distribution in the cochlea using monoclon...
8260618 - Expression of alpha-actinin in the stereocilia of hair cells of the inner ear: immunohi...
3478958 - Hair cell distributions in the normal human cochlea. a report of a european working group.
15806708 - Efficacy of an ototoxic aminoglycoside (gentamicin) on the differentiation of the inner...
15701808 - Radiological studies reveal radial differences in the architecture of the polysaccharid...
1145898 - On the availability of certain metabolites at the outer surface of normal and malignant...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  5     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-74     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Bone Marrow / physiology
Cell Division*
Colonic Neoplasms / etiology
Embryonic Induction
Endometrium / physiology
Female
Hair / physiology
Humans
Hydrazines / adverse effects
Kinetics
Mice
Nerve Fibers / physiology*
Rats
Skin Neoplasms / etiology
Skin Physiological Phenomena
Chemical
Reg. No./Substance:
0/Hydrazines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Solar cycles and malignant melanoma.
Next Document:  Selectivity and rejectivity in cancer metastasis.